Common Diuretic May Be Linked to Skin Cancer

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Nelson Vergel

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Beyond Testosterone Book by Nelson Vergel
Key clinical point: The antihypertensive agent hydrochlorothiazide (HCTZ ) is photosensitizing and may be associated with an increased risk for skin cancers in non-Hispanic white males with a history of squamous cell carcinoma (SCC).

Major finding: All four patients considered high risk based on lifetime SCC history were non-Hispanic white males with a history of HCTZ exposure, an association supported by three previously published studies.

Data sources: Medical records from 75 patients seen in a single dermatology practice over a 5-day period, and a literature search as well as relevant publications detected through a literature search spanning the years 1966-2015.

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