Combining tadalafil and sildenafil

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JohnsonC

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Have anyone in here tried combining tadalafil and sildenafil? I heard from a friend that it produces out-of-this-world erections. He got the tip from a doctor. I still wrote it off as risky and stupid until I found this study:


Study on the Effectiveness and Safety of Combining Tadalafil with Sildenafil for Erectile Dysfunction

Authors
: H. Cui, B. Liu, Z. Song, J. Fang, Y. Deng, S. Zhang, H. Wang, Z. Wang

Affiliation: State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Overview of Research

This research focused on assessing the effectiveness and safety of a long-term, low-dose treatment using tadalafil combined with sildenafil for the early-stage treatment of erectile dysfunction (ED). The study involved 180 patients with ED, who were divided equally into two groups: one receiving a daily dose of 5 mg tadalafil, and the other receiving the same daily tadalafil dose combined with 50 mg of sildenafil as required.

Evaluation Methods

The effectiveness of the treatments was measured using two tools: the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). To gauge safety, the study monitored drug tolerability and noted any adverse events.

Findings

The results showed a more pronounced improvement in erectile function in the group receiving the combined medication, particularly among patients with severe ED. This was evidenced by higher total IIEF-5 scores in the combined medication group compared to the tadalafil-only group. Specifically, scores for Question 2 of the IIEF-5, which assesses erectile function, were significantly better in the combined group for patients with moderate to severe ED. A significant improvement was also noted in Question 3 scores of the IIEF-5, but only for patients with severe ED in the combined medication group. Additionally, there was a notable improvement in responses to SEP4, SEP5, and the partner’s SEP3 in the combined medication group.

In terms of safety, there was no significant difference in the incidence of adverse events between the two groups.

Conclusion

The study suggests that the combination of tadalafil and sildenafil can significantly enhance erectile function, particularly for those with severe cases of ED, without increasing the risk of adverse events.

Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction.

1State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Abstract
This study aimed to evaluate the efficacy and safety of long-term and low-dose tadalafil combined with sildenafil as needed at the early stage of treatment for erectile dysfunction (ED). We enrolled 180 patients with ED 1 : 1 to tadalafil 5 mg once daily or once-a-day tadalafil 5 mg combined with sildenafil 50 mg as needed. The efficacy measures included the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). The safety was assessed by observing drug tolerability and adverse events. Total IIEF-5 scores of patients with severe ED in combined medication group were significantly higher than in tadalafil alone group. Question 2 scores of IIEF-5 of patients with moderate and severe ED in combined medication group were significantly higher than in tadalafil alone group. The significant improvement in question 3 scores of IIEF-5 existed only in patients with severe ED receiving combined medication. The percentage of 'yes' responses to SEP4, SEP5 and partner's SEP3 were improved significantly in combined medication group. There was no difference between two groups in the incidence of adverse events. Our results suggest that combined medication can better improve erectile function, especially for patients with severe ED.

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I have done it with mixed results. I've been taking 5mg daily Cialis for about 1.5 years. Have occasionally tried 25-50mg of sildenafil (and 12mg vardenafil) in combination with the daily Cialis.

One time with the sildenafil it was very effective. Even went twice in a row which is something I haven't been able to do since my 20s. It was almost concerning cuz the damn thing just didn't want to go away. On the other hand, there were times when I wasn't sure if it made any difference at all.
 
I think what I had was 55/12 from Empower and it worked good. Probably half that dose would be enough. It makes you so hard you could be injured if your not careful with it. It probably will not bend if you crash it.
 
I take 2.5mg Cialis per day, which does a little bit for me. I am Ok a lot of the time without it. However, I have no hesitation taking half a Viagra (50 mg) if I know I have some extended time with the wife. Its not a huge combo dose, but it certainly does work well in holding erection time (which is my issue when it hits).
 
I've done it countless times, no worries. The big things for me are timing, the Cialis take a while before it kicks in, where the Viagra kicks in pretty fast.

Empty stomach for best results, a heavy high fat meal and Viagra doesn't absorb at all for me(no stuffed nose, no flushing, no erection benefit).
 
I do a combo with daily cialis 5mg and 5-10 of Levitra that way I can eat more since Levitra is better that Viagra if your going to eat before sex. (all generic)
 
I agree with my friends these can be combined but take note that what's been discussed is low dosing, what you want to avoid is 20mg C and 50-100mg of V...low blood pressure is bad. When you combine low doses like 2.5-5mg/C and 25mg/V you can get great results.

Note too about the timing of the dosing with Cialis/Tad and then stomach contents with V...takes some pre planning.
 
Wow - I did not expect this many guys from on here to be doing this combo. I'm happy to hear you're all having great results. I will try combining 5 mg cialis in the morning with 20 mg of viagra at night. Thank you!
 
I take 5mg Cialis daily and frequently add 50mg Viagra on sex nights. I haven’t had any problems with it and it works great. My doctor approves because both are less than maximum dosage.
 
I find a dose of 5mg Cialis lasts me 48 hrs so I can do it EOD. However, the nasal congestion is terrible and I can’t breathe at night. Anyone find a way around this?
 
I find a dose of 5mg Cialis lasts me 48 hrs so I can do it EOD. However, the nasal congestion is terrible and I can’t breathe at night. Anyone find a way around this?
I’ve taken 5mg Cialis daily for many years and I don’t have any side effects from it. My nose gets stuffy when I add viagra but that wears off by morning
 
I have the impression that Cialis make more difficult to reach climax. Is this just my impression or it is real?
For some men Cialis can make it hard to reach full orgasm when having sex. The only way to know how it affects you, is by using it. I've never wanted to use Cialis or Viagra, after reading all the health benefits from using them. I finally decided to and I'm very happy I did. I'm having awesome sex with my wife. I'm happy that is very easy for her to have multi orgasms. Having a good sex life, can really make you feel close to your mate.
 
When I first started using Cialis, I did get severe back pain. Which overtime subsided. I have no issues with using 20 mg or more of Cialis. Also I like taking 100 mg of Viagra before my workouts. I do think age plays a role. Since I'm 65 and take my blood pressure regularly. Making sure it never gets too low. If I was younger, I would never consider using the high of dose.
 
When I first started using Cialis, I did get severe back pain. Which overtime subsided. I have no issues with using 20 mg or more of Cialis. Also I like taking 100 mg of Viagra before my workouts. I do think age plays a role. Since I'm 65 and take my blood pressure regularly. Making sure it never gets too low. If I was younger, I would never consider using the high of dose.

How long did it take for the back pain to subside? I recently tried 5 mg Ceebis and had to stop after day #3 due to the low back pain. It seemed to emanate from my hips up to the lower back and even down my legs a bit. It was so bad I was unable to sleep, so I stopped and after a day or so the pain subsided.
 
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How long did it take for the back pain to subside? I recently tried 5 mg Ceebis and had to stop after day #3 due to the low back pain. It seemed to emanate from my hips up to the lower back and even down my legs a bit. It was so bad I was unable to sleep, so I stopped and after a day or so the pain subsided.
After a few weeks, the back pain started slowly going away. It did take a full year before the pain fully subsided. What really help make my back feel better. Good hard full squats, for some reason it always helps eliminate my back pain.
 
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