Have anyone in here tried combining tadalafil and sildenafil? I heard from a friend that it produces out-of-this-world erections. He got the tip from a doctor. I still wrote it off as risky and stupid until I found this study:
Study on the Effectiveness and Safety of Combining Tadalafil with Sildenafil for Erectile Dysfunction
Authors: H. Cui, B. Liu, Z. Song, J. Fang, Y. Deng, S. Zhang, H. Wang, Z. Wang
Affiliation: State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Overview of Research
This research focused on assessing the effectiveness and safety of a long-term, low-dose treatment using tadalafil combined with sildenafil for the early-stage treatment of erectile dysfunction (ED). The study involved 180 patients with ED, who were divided equally into two groups: one receiving a daily dose of 5 mg tadalafil, and the other receiving the same daily tadalafil dose combined with 50 mg of sildenafil as required.
Evaluation Methods
The effectiveness of the treatments was measured using two tools: the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). To gauge safety, the study monitored drug tolerability and noted any adverse events.
Findings
The results showed a more pronounced improvement in erectile function in the group receiving the combined medication, particularly among patients with severe ED. This was evidenced by higher total IIEF-5 scores in the combined medication group compared to the tadalafil-only group. Specifically, scores for Question 2 of the IIEF-5, which assesses erectile function, were significantly better in the combined group for patients with moderate to severe ED. A significant improvement was also noted in Question 3 scores of the IIEF-5, but only for patients with severe ED in the combined medication group. Additionally, there was a notable improvement in responses to SEP4, SEP5, and the partner’s SEP3 in the combined medication group.
In terms of safety, there was no significant difference in the incidence of adverse events between the two groups.
Conclusion
The study suggests that the combination of tadalafil and sildenafil can significantly enhance erectile function, particularly for those with severe cases of ED, without increasing the risk of adverse events.
Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction.
1State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Abstract
This study aimed to evaluate the efficacy and safety of long-term and low-dose tadalafil combined with sildenafil as needed at the early stage of treatment for erectile dysfunction (ED). We enrolled 180 patients with ED 1 : 1 to tadalafil 5 mg once daily or once-a-day tadalafil 5 mg combined with sildenafil 50 mg as needed. The efficacy measures included the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). The safety was assessed by observing drug tolerability and adverse events. Total IIEF-5 scores of patients with severe ED in combined medication group were significantly higher than in tadalafil alone group. Question 2 scores of IIEF-5 of patients with moderate and severe ED in combined medication group were significantly higher than in tadalafil alone group. The significant improvement in question 3 scores of IIEF-5 existed only in patients with severe ED receiving combined medication. The percentage of 'yes' responses to SEP4, SEP5 and partner's SEP3 were improved significantly in combined medication group. There was no difference between two groups in the incidence of adverse events. Our results suggest that combined medication can better improve erectile function, especially for patients with severe ED.
__________________________
No prescription tadalafil (Cialis) and other ED meds
Coupon: EXCELMALE20 (20 percent off)
Cheaper to buy 20 mg and cut them in two if needed
Study on the Effectiveness and Safety of Combining Tadalafil with Sildenafil for Erectile Dysfunction
Authors: H. Cui, B. Liu, Z. Song, J. Fang, Y. Deng, S. Zhang, H. Wang, Z. Wang
Affiliation: State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Overview of Research
This research focused on assessing the effectiveness and safety of a long-term, low-dose treatment using tadalafil combined with sildenafil for the early-stage treatment of erectile dysfunction (ED). The study involved 180 patients with ED, who were divided equally into two groups: one receiving a daily dose of 5 mg tadalafil, and the other receiving the same daily tadalafil dose combined with 50 mg of sildenafil as required.
Evaluation Methods
The effectiveness of the treatments was measured using two tools: the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). To gauge safety, the study monitored drug tolerability and noted any adverse events.
Findings
The results showed a more pronounced improvement in erectile function in the group receiving the combined medication, particularly among patients with severe ED. This was evidenced by higher total IIEF-5 scores in the combined medication group compared to the tadalafil-only group. Specifically, scores for Question 2 of the IIEF-5, which assesses erectile function, were significantly better in the combined group for patients with moderate to severe ED. A significant improvement was also noted in Question 3 scores of the IIEF-5, but only for patients with severe ED in the combined medication group. Additionally, there was a notable improvement in responses to SEP4, SEP5, and the partner’s SEP3 in the combined medication group.
In terms of safety, there was no significant difference in the incidence of adverse events between the two groups.
Conclusion
The study suggests that the combination of tadalafil and sildenafil can significantly enhance erectile function, particularly for those with severe cases of ED, without increasing the risk of adverse events.
Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction.
1State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Abstract
This study aimed to evaluate the efficacy and safety of long-term and low-dose tadalafil combined with sildenafil as needed at the early stage of treatment for erectile dysfunction (ED). We enrolled 180 patients with ED 1 : 1 to tadalafil 5 mg once daily or once-a-day tadalafil 5 mg combined with sildenafil 50 mg as needed. The efficacy measures included the 5-item version of the International Index of Erectile Function (IIEF-5) and the Sexual Encounter Profile (SEP). The safety was assessed by observing drug tolerability and adverse events. Total IIEF-5 scores of patients with severe ED in combined medication group were significantly higher than in tadalafil alone group. Question 2 scores of IIEF-5 of patients with moderate and severe ED in combined medication group were significantly higher than in tadalafil alone group. The significant improvement in question 3 scores of IIEF-5 existed only in patients with severe ED receiving combined medication. The percentage of 'yes' responses to SEP4, SEP5 and partner's SEP3 were improved significantly in combined medication group. There was no difference between two groups in the incidence of adverse events. Our results suggest that combined medication can better improve erectile function, especially for patients with severe ED.
__________________________
No prescription tadalafil (Cialis) and other ED meds
Coupon: EXCELMALE20 (20 percent off)
Cheaper to buy 20 mg and cut them in two if needed
