Nelson Vergel
Founder, ExcelMale.com
Combination Therapy Of Tadalafil And Pentoxifylline In Severe Erectile Dysfunction; A Prospective Randomized Trial.
The aim of the study was to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire.
Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire.
Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifyl-line. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student's unpaired t-test, paired t-test, chi square test. p-value < 0. 05 was considered statistically significant.
Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78. 6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86. 6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90. 7±15. 2%, group B 95. 6±13. 4%; p value - 0. 014). We found this difference even more statistically significant in patients with severe ED (group A 72. 7±47. 2%, group B 132. 3±54. 3%; p value - 0. 000). There was no significant difference in between the two groups with regards to occur-rence of side effects.
Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.
Polski przeglad chirurgiczny. 2015 Aug 01 [Epub]
Santosh Kumar, Rajesh Roat, Swati Agrawal, Kumar Jayant, Ravimohan S Mavuduru, Shrawan Kuma
The aim of the study was to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire.
Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire.
Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifyl-line. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student's unpaired t-test, paired t-test, chi square test. p-value < 0. 05 was considered statistically significant.
Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78. 6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86. 6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90. 7±15. 2%, group B 95. 6±13. 4%; p value - 0. 014). We found this difference even more statistically significant in patients with severe ED (group A 72. 7±47. 2%, group B 132. 3±54. 3%; p value - 0. 000). There was no significant difference in between the two groups with regards to occur-rence of side effects.
Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.
Polski przeglad chirurgiczny. 2015 Aug 01 [Epub]
Santosh Kumar, Rajesh Roat, Swati Agrawal, Kumar Jayant, Ravimohan S Mavuduru, Shrawan Kuma
