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I am curious if there is any way to have long term success on Clomid despite being prone to high SHBG. I have always been over the range, my SHBG was at 60 (15-55) even on injections.

I tried a Clomid restart and it shot my SHBG up to 90 (15-55).

So after 4 months on Clomid, my total t was at 720 but my free t was 11 (9-26) and my estrogen never got above 16 (8-35) so I had all of the low e2 symptoms and low T symptoms on Clomid.

After I came off clomid, I had bloods at 6 weeks and my T had dropped to 473 and free t was down to 6 (9-26) and e2 around 14.

So essentially, the Clomid restart didn’t work and I continued to feel worse until I restarted injections.

Is there any way to have success on Clomid if you are prone to high SHBG?

[QUOTE="cigpk, post: 134145, member: 34003"] I am curious if there is any way to have long term success on Clomid despite being prone to high SHBG. I have always been over the range, my SHBG was at 60 (15-55) even on injections. I tried a Clomid restart and it shot my SHBG up to 90 (15-55). So after 4 months on Clomid, my total t was at 720 but my free t was 11 (9-26) and my estrogen never got above 16 (8-35) so I had all of the low e2 symptoms and low T symptoms on Clomid. After I came off clomid, I had bloods at 6 weeks and my T had dropped to 473 and free t was down to 6 (9-26) and e2 around 14. So essentially, the Clomid restart didn’t work and I continued to feel worse until I restarted injections. Is there any way to have success on Clomid if you are prone to high SHBG? [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038