Clinical Trial on the Effect of TRT on Alzheimer's to Begin

Jinzang

Member
The press release says:

Macquarie University Hospital is participating in what will be the largest clinical trial to date assessing the effect of testosterone supplementation on reducing amyloid – a protein that develops in the part of the brain that affects memory and learning. Beta amyloid accumulation in the brain is a known cause of Alzheimer’s disease.

Participants will either receive testosterone supplementation alone or in combination with fish oil to determine if the amyloid load in the brain can be reduced, as well as whether the supplementation affects performance on tests of memory, cognition and function.

The ‘TotAL’ Trial will take 18 months from start to finish with 56 weeks of treatment and involve several hundred participants. The clinical part of the study is being led by MQ Health’s Professor David Gillatt and part of the Hospital’s urology team specialising in men’s health and male hormone therapies.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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