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Cialis & Raynaud's Disease
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<blockquote data-quote="CoastWatcher" data-source="post: 93045" data-attributes="member: 2624"><p>Raynaud's Disease, a rheumatological disorder, is the sudden constriction of blood vessels in the extremities, particularly in the hands, causing sharp pain, blanching, loss of sensation, and - in extreme cases - tissue destruction. More often seen in northern climates, and more prevalent in men, it is a disorder that is managed, not cured. Studies suggest that Cialis (Tadalafil) is an effective adjuctive therapy for managing Raynaud's.</p><p> </p><p></p><ul> <li data-xf-list-type="ul">Patients having four or more Raynaud's attacks per week despite being on vasodilators were randomized to receive either placebo or tadalafil (20 mg) on alternate days as add-on therapy to their current vasodilators for 6 weeks.</li> </ul><p>Primary endpoints were improvement in the daily frequency and duration of Raynaud's episodes. Secondary outcome measures were healing of existing and appearance of new digital ulcers. <strong>Results.</strong> </p><p></p><ul> <li data-xf-list-type="ul">Twenty-four of 25 recruited patients completed the study. All the patients were receiving calcium channel blockers and in addition 18 were receiving other vasodilators.</li> <li data-xf-list-type="ul">During tadalafil therapy significant improvement in mean daily frequency, mean daily duration of RP and mean daily RCS were observed as compared with baseline and placebo.</li> <li data-xf-list-type="ul">All the 24 digital lesions healed during tadalafil therapy as compared with 3/13 during the placebo treatment (<em>P</em> < 0.0001).</li> <li data-xf-list-type="ul">No serious adverse event was observed.</li> </ul><p><strong></strong></p><p><strong>Conclusion.</strong> Tadalafil as add-on therapy improves symptoms of RP, heals and prevents new DUs and improves QoL in patients with resistant secondary RP.</p><p></p><p>"Efficacy of tadalafil in secondary Raynaud’s phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial," <em>Rheumatology December 2010, </em><a href="https://academic.oup.com/rheumatology/article/49/12/2420/1791021" target="_blank">https://academic.oup.com/rheumatology/article/49/12/2420/1791021</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 93045, member: 2624"] Raynaud's Disease, a rheumatological disorder, is the sudden constriction of blood vessels in the extremities, particularly in the hands, causing sharp pain, blanching, loss of sensation, and - in extreme cases - tissue destruction. More often seen in northern climates, and more prevalent in men, it is a disorder that is managed, not cured. Studies suggest that Cialis (Tadalafil) is an effective adjuctive therapy for managing Raynaud's. [LIST] [*]Patients having four or more Raynaud's attacks per week despite being on vasodilators were randomized to receive either placebo or tadalafil (20 mg) on alternate days as add-on therapy to their current vasodilators for 6 weeks. [/LIST] Primary endpoints were improvement in the daily frequency and duration of Raynaud's episodes. Secondary outcome measures were healing of existing and appearance of new digital ulcers. [B]Results.[/B] [LIST] [*]Twenty-four of 25 recruited patients completed the study. All the patients were receiving calcium channel blockers and in addition 18 were receiving other vasodilators. [*]During tadalafil therapy significant improvement in mean daily frequency, mean daily duration of RP and mean daily RCS were observed as compared with baseline and placebo. [*]All the 24 digital lesions healed during tadalafil therapy as compared with 3/13 during the placebo treatment ([I]P[/I] < 0.0001). [*]No serious adverse event was observed. [/LIST] [B] Conclusion.[/B] Tadalafil as add-on therapy improves symptoms of RP, heals and prevents new DUs and improves QoL in patients with resistant secondary RP. "Efficacy of tadalafil in secondary Raynaud’s phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial," [I]Rheumatology December 2010, [/I][URL]https://academic.oup.com/rheumatology/article/49/12/2420/1791021[/URL] [/QUOTE]
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