DaviSh, tadalafil does decrease estradiol, and higher doses like you are using will of course decrease estradiol more than lower doses.
However, as you are using research chem liquid tadalafil, your problem may be simpler. Does the research chemical company you are using also sell aromatase inhibitors (arimidex, letrozole, aromasin, etc.)? Perhaps they are making their liquid products using the same lab equipment, and small amounts of their other products, like the AI's, are contaminating the liquid tadalafil. Or perhaps the raw ingredients the research company is using (all these research companies use raw powders imported from China) were processed on the same equipment as powders containing an AI. The research chemical business is that kind of gray market, quasi-legal kind of environment where you really have to watch what you are buying, and you don't know for sure what is in the product unless you are having it tested.
I would try switching to a different supplier of tadalafil, perhaps in tablet form instead of liquid, and see if the problems continue. And perhaps try dropping your dose, as 60mg is an awfully high dose of tadalafil (if it really is tadalafil.)
Just a thought, and best wishes to you.
