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Cardiovascular risk of energy drinks: Caffeine and taurine facilitate ventricular arrhythmias in a sensitive whole-heart model
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<blockquote data-quote="tareload" data-source="post: 231815"><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/[/URL]</p><p></p><p></p><p>The current investigation has several clinical implications. First, compounds directed toward modifying Glu or Tau metabolism are prospective antiarrhythmic agents. Indeed, a new chelate coordination compound, Tau magnesium coordination compound (TMCC), was recently synthesized and tested as an antiarrhythmic drug [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B40" target="_blank">39</a>]. The antiarrhythmic effects of TMCC were similar to those of amiodarone, as demonstrated in a cesium chloride-induced arrhythmia model. Second, our data are consistent with a previous report indicating that Tau metabolism might be pathophysiologically involved in AF under conditions of excessive thyroid hormone production [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B41" target="_blank">40</a>]. Yet another study utilized a Tau transporter knockout mouse model to show that depletion of the intracellular Tau pool via blockade of Tau uptake from the extracellular space resulted in a cardiomyopathic condition [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B42" target="_blank">41</a>]. Again, further basic and clinical studies regarding Tau metabolism are required to establish the putative function of this amino acid in the pathogenesis of cardiac arrhythmias and AF.</p></blockquote><p></p>
[QUOTE="tareload, post: 231815"] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/[/URL] The current investigation has several clinical implications. First, compounds directed toward modifying Glu or Tau metabolism are prospective antiarrhythmic agents. Indeed, a new chelate coordination compound, Tau magnesium coordination compound (TMCC), was recently synthesized and tested as an antiarrhythmic drug [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B40']39[/URL]]. The antiarrhythmic effects of TMCC were similar to those of amiodarone, as demonstrated in a cesium chloride-induced arrhythmia model. Second, our data are consistent with a previous report indicating that Tau metabolism might be pathophysiologically involved in AF under conditions of excessive thyroid hormone production [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B41']40[/URL]]. Yet another study utilized a Tau transporter knockout mouse model to show that depletion of the intracellular Tau pool via blockade of Tau uptake from the extracellular space resulted in a cardiomyopathic condition [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736607/#B42']41[/URL]]. Again, further basic and clinical studies regarding Tau metabolism are required to establish the putative function of this amino acid in the pathogenesis of cardiac arrhythmias and AF. [/QUOTE]
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Cardiovascular risk of energy drinks: Caffeine and taurine facilitate ventricular arrhythmias in a sensitive whole-heart model
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