Biotin May Interfere With Blood Tests

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Biotin supplements taken at common over-the-counter doses can interfere with the results of certain hormone assays, giving falsely high or low results that could lead to a misdiagnosis, researchers reported. Biotin supplements, at very large doses, 10-15mg (333-fold greater than the dietary recommendation), have become popular for the presumptive benefits of stimulating hair growth, diabetes, lipid disorders, and diabetic peripheral neuropathy.

High doses of biotin may interfere with lab tests because biotin is a common component of many immunoassays in the form of biotinylated antibodies or analogues.

"Clinicians may want to ask about biotin ingestion even if assay results are not suspect because biotin interference can cause either falsely not or abnormal results. It may be advisable for patients to stop taking biotin, preferably for a week...before undergoing laboratory testing."

Medpage Today, 26 September 2017

https://www.medpagetoday.com/Endocr...id=nl_mpt_DHE_2017-09-27&eun=g777076d0r&pos=1
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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