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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
BIG QUESTION MARK !
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<blockquote data-quote="Cataceous" data-source="post: 266952" data-attributes="member: 38109"><p>Having a predisposition does not mean you're going to clot anyway. The data do not rule out testosterone therapy as a precipitating factor, and the authors of the cited study assert causality: "... testosterone therapy (TT) interacted with thrombophilia–hypofibrinolysis, leading to venous thromboembolism (VTE)." In support, "The potency of the prothrombotic stimulus of exogenous TT is testified to by the finding that 11 men with thrombophilia sustained a first thrombotic event on TT, and while continuing TT, despite adequate anticoagulation, sustained a second VTE. Moreover, 6 of these 11 men, remaining on TT and still anticoagulated, had a third VTE." Further, "Only 1 of the 67 TT patients had a thrombotic event preceding TT, so that using history of thrombosis in lieu of measurement of thrombophilia would not be predictive in predicting the risk of thrombosis in patients about to receive TT."</p><p></p><p>Asking for an "epidemic of blood clots" as evidence is disingenuous. You're aware that the absolute incidence of these events is low. Even a five-fold increase in risk would not result in an epidemic. Handwaving about "hundreds of studies" gets you nowhere. You're aware that no quality RCT has been done, which contributes to the continuing uncertainty. My take is that if you're not in one of the high-risk groups and your testosterone dosing is physiological then the issue is not worth losing sleep over. Of course the OP mentioned taking 500 mg TC per week, and his predisposition to clotting is unknown.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 266952, member: 38109"] Having a predisposition does not mean you're going to clot anyway. The data do not rule out testosterone therapy as a precipitating factor, and the authors of the cited study assert causality: "... testosterone therapy (TT) interacted with thrombophilia–hypofibrinolysis, leading to venous thromboembolism (VTE)." In support, "The potency of the prothrombotic stimulus of exogenous TT is testified to by the finding that 11 men with thrombophilia sustained a first thrombotic event on TT, and while continuing TT, despite adequate anticoagulation, sustained a second VTE. Moreover, 6 of these 11 men, remaining on TT and still anticoagulated, had a third VTE." Further, "Only 1 of the 67 TT patients had a thrombotic event preceding TT, so that using history of thrombosis in lieu of measurement of thrombophilia would not be predictive in predicting the risk of thrombosis in patients about to receive TT." Asking for an "epidemic of blood clots" as evidence is disingenuous. You're aware that the absolute incidence of these events is low. Even a five-fold increase in risk would not result in an epidemic. Handwaving about "hundreds of studies" gets you nowhere. You're aware that no quality RCT has been done, which contributes to the continuing uncertainty. My take is that if you're not in one of the high-risk groups and your testosterone dosing is physiological then the issue is not worth losing sleep over. Of course the OP mentioned taking 500 mg TC per week, and his predisposition to clotting is unknown. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
BIG QUESTION MARK !
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