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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Best TRT administration. Injectable vs Oral
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<blockquote data-quote="madman" data-source="post: 189220" data-attributes="member: 13851"><p>This would only be with orals that are c-17 alpha-alkylated (resistant to first-pass hepatic metabolism) such as methyltestosterone, anavar, stanozolol, methandrostenolone, oxymetholone, and fluoxymesterone.</p><p></p><p>Of those listed above, only 2 were prescribed for trt in men.</p><p></p><p>Methyltestosterone was the most commonly used oral for decades and in some cases, fluoxymesterone had been used but they are no longer in use due to possible liver toxicity and we have many safer options now.</p><p></p><p>These were replaced by non-17-alpha alkylated oral TU (testosterone undecanoate). The older formulation of TU (T-ester that is absorbed via the intestinal lymphatic system thus bypassing the portal circulation) replaced the c-17 alpha-alkylated orals. </p><p></p><p>The downfall of the older formulations was high amounts of dietary fat needed to be taken with the capsule to improve absorption which unfortunately resulted in significant variability in patients serum T level</p><p></p><p>They were again reformulated to try and reduce the effect of dietary fat but the low dose of TU in the capsule required the patient to take several capsules (3 or more daily) and even then some men were not able to achieve average T levels in the normal range. </p><p></p><p>Recently with the FDA approval of oral TU (Jatenzo) in the US the absorption issues of past formulations are no longer the case as TU was formulated in a unique self-emulsifying drug delivery system which allows the capsule to be absorbed when taken with food without the addition of high dietary fat but again, unfortunately, the main downfall is the blood levels achieved are modest at best.</p></blockquote><p></p>
[QUOTE="madman, post: 189220, member: 13851"] This would only be with orals that are c-17 alpha-alkylated (resistant to first-pass hepatic metabolism) such as methyltestosterone, anavar, stanozolol, methandrostenolone, oxymetholone, and fluoxymesterone. Of those listed above, only 2 were prescribed for trt in men. Methyltestosterone was the most commonly used oral for decades and in some cases, fluoxymesterone had been used but they are no longer in use due to possible liver toxicity and we have many safer options now. These were replaced by non-17-alpha alkylated oral TU (testosterone undecanoate). The older formulation of TU (T-ester that is absorbed via the intestinal lymphatic system thus bypassing the portal circulation) replaced the c-17 alpha-alkylated orals. The downfall of the older formulations was high amounts of dietary fat needed to be taken with the capsule to improve absorption which unfortunately resulted in significant variability in patients serum T level They were again reformulated to try and reduce the effect of dietary fat but the low dose of TU in the capsule required the patient to take several capsules (3 or more daily) and even then some men were not able to achieve average T levels in the normal range. Recently with the FDA approval of oral TU (Jatenzo) in the US the absorption issues of past formulations are no longer the case as TU was formulated in a unique self-emulsifying drug delivery system which allows the capsule to be absorbed when taken with food without the addition of high dietary fat but again, unfortunately, the main downfall is the blood levels achieved are modest at best. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Best TRT administration. Injectable vs Oral
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