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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Best time to inject testosterone?
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<blockquote data-quote="Cataceous" data-source="post: 190615" data-attributes="member: 38109"><p>You may have a point, but for the wrong reason. It only seems like a low dose because most guys on TRT are overdosing. The average man produces around 6 mg of testosterone per day. 10 mg of testosterone cypionate contains 7 mg of testosterone. But the average man has diurnal variation in his serum testosterone, so assuming we need to match peak levels, and assuming that daily cypionate injections cause nearly constant levels, then we must derate the dose by 20%, yielding an equivalent of 5.6 mg per day. This is only a little below average. However, there is another factor in this case: [USER=41397]@IndyColts18to88[/USER] is a large man at 6'4" and 270 lbs. There is research demonstrating that the serum testosterone response to a fixed exogenous dose correlates negatively with body mass. I don't recall the figures involved, but assume the dose should be derated by another 25%. This is pushing daily testosterone intake down to around 4 mg, which is getting on the low side. One additional factor is that his SHBG is a little below average, which reduces total testosterone at a fixed exogenous dose. If I had to guess I'd say 10 mg TC per day would put his serum testosterone in the 400s ng/dL. This is still above his recent measurements in the 200s and 300s.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 190615, member: 38109"] You may have a point, but for the wrong reason. It only seems like a low dose because most guys on TRT are overdosing. The average man produces around 6 mg of testosterone per day. 10 mg of testosterone cypionate contains 7 mg of testosterone. But the average man has diurnal variation in his serum testosterone, so assuming we need to match peak levels, and assuming that daily cypionate injections cause nearly constant levels, then we must derate the dose by 20%, yielding an equivalent of 5.6 mg per day. This is only a little below average. However, there is another factor in this case: [USER=41397]@IndyColts18to88[/USER] is a large man at 6'4" and 270 lbs. There is research demonstrating that the serum testosterone response to a fixed exogenous dose correlates negatively with body mass. I don't recall the figures involved, but assume the dose should be derated by another 25%. This is pushing daily testosterone intake down to around 4 mg, which is getting on the low side. One additional factor is that his SHBG is a little below average, which reduces total testosterone at a fixed exogenous dose. If I had to guess I'd say 10 mg TC per day would put his serum testosterone in the 400s ng/dL. This is still above his recent measurements in the 200s and 300s. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Best time to inject testosterone?
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