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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Back on Pregnenolone - Interesting Consequences
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<blockquote data-quote="DragonBits" data-source="post: 140049" data-attributes="member: 18023"><p>It's possible, how did Dr. Saya respond to your question?</p><p></p><p>IMO pregnenelone's effects seem highly subjective, so it would be more difficult to determine if they are real or imagined.</p><p></p><p>I prefer if the effects show up in a blood test. Maybe a test of neurotransmitters would show a change? Neurotransmitters affect sleep, mood, depression and anxiety.</p><p></p><p>Every time I look into the details of hormone cascades, different enzymes and paths affected it turns much more complicated with hormone feed backs, hormones affected by supplements, endocrine disruptors can also alter the amount of hormone synthesized how fast it is degraded, the same hormones generated by different glans/cells, or the way in which a target cell responds. </p><p></p><p>There are serum levels of hormones like DHT that don't reflect levels inside of glans like the prostate. Brain levels of hormones that are only located within the brain.</p><p></p><p>HCG isn't LH, it isn't bioidentical, and does behave differently than LH. Whether that matters or not, I don't know. When testosterone is too high, the body lowers LH to maintain a level that the body deems is appropriate. Introducing HCG while also maintaining a high level of testosterone isn't a natural situation. Does that create any problems, again, I don't know.</p><p></p><p>We tend to focus on endocrine hormones because they are easy to measure and are distributed in serum.</p><p></p><p>But there are that we don't often talk about..</p><ul> <li data-xf-list-type="ul"><strong>Paracrine action</strong>: the hormone acts locally by diffusing from its source to target cells in the neighborhood.</li> <li data-xf-list-type="ul"><strong>Autocrine action</strong>: the hormone acts on the same cell that produced it.</li> </ul><p>My point is it's very difficult to predict what introducing a exogenous hormone will result in after all these influences. I could see a hormone producing a result in the first few days then feed backs negating those results after a time. </p><p></p><p>Testosterone alone seems pretty simple.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 140049, member: 18023"] It's possible, how did Dr. Saya respond to your question? IMO pregnenelone's effects seem highly subjective, so it would be more difficult to determine if they are real or imagined. I prefer if the effects show up in a blood test. Maybe a test of neurotransmitters would show a change? Neurotransmitters affect sleep, mood, depression and anxiety. Every time I look into the details of hormone cascades, different enzymes and paths affected it turns much more complicated with hormone feed backs, hormones affected by supplements, endocrine disruptors can also alter the amount of hormone synthesized how fast it is degraded, the same hormones generated by different glans/cells, or the way in which a target cell responds. There are serum levels of hormones like DHT that don't reflect levels inside of glans like the prostate. Brain levels of hormones that are only located within the brain. HCG isn't LH, it isn't bioidentical, and does behave differently than LH. Whether that matters or not, I don't know. When testosterone is too high, the body lowers LH to maintain a level that the body deems is appropriate. Introducing HCG while also maintaining a high level of testosterone isn't a natural situation. Does that create any problems, again, I don't know. We tend to focus on endocrine hormones because they are easy to measure and are distributed in serum. But there are that we don't often talk about.. [LIST] [*][B]Paracrine action[/B]: the hormone acts locally by diffusing from its source to target cells in the neighborhood. [*][B]Autocrine action[/B]: the hormone acts on the same cell that produced it. [/LIST] My point is it's very difficult to predict what introducing a exogenous hormone will result in after all these influences. I could see a hormone producing a result in the first few days then feed backs negating those results after a time. Testosterone alone seems pretty simple. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Back on Pregnenolone - Interesting Consequences
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