Article: High Doses of Testosterone Increase Liver Toxicity of Trans Fats (In Mice)

[Jinzang]

High Doses of T Increase Liver Toxicity of Trans Fats (In Mice)

We're talking anabolic doses, 10 or 20 mg/kg, which is 800 mg or 1600 mg for the average weight man. It looks like the toxic effects of trans fats are increased by testosterone. The abstract says:

We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholic fatty liver disease (NAFLD) in mice treated with a diet rich in trans fatty acids. Seventy-two mice were equally randomized into six groups and treated with a standard diet (SD) or high-fat diet (HFD) alone or combined with testosterone cypionate (10 or 20 mg/kg) for 12 weeks. When combined with a HFD, AS reduced plasma HDL cholesterol levels. It also upregulated SREBP-1, PPARα, SCD-1 and ACOX1 gene expression; plasma and hepatic triglyceride levels; oxidative stress; circulating hepatic transaminase levels and NAFLD severity.