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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Appropriate Starting Dose for Propionate?
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<blockquote data-quote="Cataceous" data-source="post: 158185" data-attributes="member: 38109"><p>The part about testosterone is true, but will be misunderstood; your serum testosterone half-life is independent of SHBG. Higher SHBG makes for a longer excretion time constant, but as I've noted many times, the excretion time constant is on the order of minutes to hours, and is completely overridden by the absorption time constant, which is on the order of days (~0.8 days for propionate, ~5 days for cypionate).</p><p></p><p>Thus I don't see why estradiol "must stay elevated for longer". For the most part estradiol is simply lagging testosterone. My argument continues to be that for the same testosterone dose, higher SHBG yields higher total hormone levels, but the same free hormone levels.</p><p></p><p>Conventional wisdom says that estradiol is more of a problem with low SHBG. I suspect this is because the ratio of free testosterone to free estradiol decreases as SHBG goes lower.</p><p></p><p>It's nice to see that the free estradiol calculator continues to give values that correspond well with your measured values.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 158185, member: 38109"] The part about testosterone is true, but will be misunderstood; your serum testosterone half-life is independent of SHBG. Higher SHBG makes for a longer excretion time constant, but as I've noted many times, the excretion time constant is on the order of minutes to hours, and is completely overridden by the absorption time constant, which is on the order of days (~0.8 days for propionate, ~5 days for cypionate). Thus I don't see why estradiol "must stay elevated for longer". For the most part estradiol is simply lagging testosterone. My argument continues to be that for the same testosterone dose, higher SHBG yields higher total hormone levels, but the same free hormone levels. Conventional wisdom says that estradiol is more of a problem with low SHBG. I suspect this is because the ratio of free testosterone to free estradiol decreases as SHBG goes lower. It's nice to see that the free estradiol calculator continues to give values that correspond well with your measured values. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Appropriate Starting Dose for Propionate?
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