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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone succeeding in increasing T with Kisspeptin while on TRT
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<blockquote data-quote="Cataceous" data-source="post: 239553" data-attributes="member: 38109"><p>Although <a href="https://www.excelmale.com/forum/threads/kisspeptin-suppression-under-trt-can-it-affect-mood-and-libido.21374/" target="_blank">speculative</a>, it's possible that taking kisspeptin-10 with TRT could confer benefits that are independent of HPTA effects. The problem with combining kisspeptin with TRT is that you won't overcome HPTA suppression unless you <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/" target="_blank">also take a SERM</a>. In other words, even if you stimulate the hypothalamus to produce GnRH, you likely will not overcome the negative feedback of estrogens at the pituitary, and therefore will not reap the benefits of normalizing LH and FSH, let alone increasing testosterone. This also assumes that the reason for TRT is not due a problem with the pituitary. But my impression is that the majority of secondary hypogonadism stems from hypothalamic dysfunction—or other brain-mediated suppression of normal hypothalamic function.</p><p></p><p>Overall it's an area that needs more research. In the future it may become common practice to add kisspeptin to TRT if there is evidence of systemic suppression. It's not clear how the U.S. will get there given that kisspetin-10 cannot be legally prescribed here. Who's going to spend the millions of dollars to get FDA approval? Perhaps a company would take it on if it turns out to be a viable treatment for secondary hypogonadism. </p><p></p><p>Is the doctor you talked to U.S.-based? If so how are his patients getting kisspeptin?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 239553, member: 38109"] Although [URL='https://www.excelmale.com/forum/threads/kisspeptin-suppression-under-trt-can-it-affect-mood-and-libido.21374/']speculative[/URL], it's possible that taking kisspeptin-10 with TRT could confer benefits that are independent of HPTA effects. The problem with combining kisspeptin with TRT is that you won't overcome HPTA suppression unless you [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/']also take a SERM[/URL]. In other words, even if you stimulate the hypothalamus to produce GnRH, you likely will not overcome the negative feedback of estrogens at the pituitary, and therefore will not reap the benefits of normalizing LH and FSH, let alone increasing testosterone. This also assumes that the reason for TRT is not due a problem with the pituitary. But my impression is that the majority of secondary hypogonadism stems from hypothalamic dysfunction—or other brain-mediated suppression of normal hypothalamic function. Overall it's an area that needs more research. In the future it may become common practice to add kisspeptin to TRT if there is evidence of systemic suppression. It's not clear how the U.S. will get there given that kisspetin-10 cannot be legally prescribed here. Who's going to spend the millions of dollars to get FDA approval? Perhaps a company would take it on if it turns out to be a viable treatment for secondary hypogonadism. Is the doctor you talked to U.S.-based? If so how are his patients getting kisspeptin? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone succeeding in increasing T with Kisspeptin while on TRT
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