Anticonvulsants for low SHBG

[mrhat75]

I stumbled across this article: http://www.defymedical.com/blog/item/23-elevated-estradiol-during-trt-to-treat-or-not-to-treat

It mentions drugs such as phenytoin and carbemazapime. I found a few studies, including these: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1027564
https://www.ncbi.nlm.nih.gov/pubmed/1868812

I don't have access to the full articles unfortunately. I did find a mention of them here, but no further detail: https://www.excelmale.com/content.php?317-ExcelMale-com-Guide-to-Testosterone-Replacement

I have googled around a bit more and haven't really found any discussions about these drugs. Does anyone know if they have ever been prescribed for the purpose of increasing SHBG? I will throw it out there to Nurse Jill at my Monday follow up appointment. Interesting.

 

[Nelson Vergel]

These drugs increase prolactin, fat mass, ED, and fatigue. Stay away from them if you do not need them.

 

[Jpin22]

These drugs increase prolactin, fat mass, ED, and fatigue. Stay away from them if you do not need them.

I think for people with low SHBG, fat mass, ED, and fatigue may already be a problem. I find myself largely non responsive to TRT presumably due to low out of range SHBG.

Atleast from what ive read, ED and fatmass gain on anti-convulsants like Phenytoin is from a decrease in free testosterone which people with low SHBG usually (not always) have levels of free testosterone high out of range. Im not advocating the use of these drugs (especially without medical supervision) however it would be interesting to see what if any impact someone on low SHBG would have on them.