Another Study Shows CV Benefits from TRT

Jinzang

Member
A ten year study found that hypogonadal men prescribed testosterone undecanoate had fewer major adverse cardiovascular events (MACE) than those who did not receive testosterone. The study also found other cardiovascular markers, such as blood pressure and heart rate imporved on TRT. The results were reported at the annual meating of the American Association of Clinical Endocrinologists. The news report says:

According to the 10-year outcomes of hypogonadal men, fewer men experienced death from a major adverse cardiovascular events (MACE) while on testosterone undecanoate treatment compared with hypogonadal men who weren't on testosterone treatment (4% vs 21.7%). The analysis included a total of 805 men with hypogonadism, defined a a total testosterone of ≤350 ng/dL. Of this group, 676 had clinically defined hypertension or a BP reading of 130/85 mmHg or higher. A total of 376 of these hypogonadal men with hypertension then elected to receive the 3-monthly testosterone undecanoate injections, while 300 men opted against testosterone therapy, and served as the study's controls.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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