Ahh please please help. On TRT and I've completely crashed my libido and SHBG...how??

lloydtrt

New Member
You guys were helpful in the past so I'm hoping you can help me through this troubling time. Thank you in advance!


30 yo male.


Active and healthy. Good muscle mass and body hair.
Please bare with me as I quote blood tests in percentiles of the range, I can gather the actual data if there is a need.


Lifelong symptoms of low T including low drive, ED, and gyno that was corrected by surgery years ago.


Feb 2017.
T - 60th%
SHBG - 90th%
Free T - 20th%
E - 85th%
Prolactin - 95th%
LH - 55th%
FSH - 60th%
Thyroid panel normal.
Lipid panel normal.
Sugar panel normal.
Cholesterol panel normal.


I dosed Caber 1x/week to bring prolactin levels down and searched for a doc to treat me with TRT eventually going with something like Defy.


In September 2017 I began injecting 60mg Test E 3x/week with no AI and no HCG. Result? Epic. Morning wood, intense sex drive, euphoria, no lethargy.


These effects leveled off slightly after the 1 month honeymoon and I also switched to a "reputable" UGL in the meantime to save money, essentially keeping the same Test protocol and adding 200 IU HCG 3x/week.


Got bloods done in January 2017 to SHOCKING results.
T - 250th%
E - 110th%
Free T - 130th%
SHBG - 60th%
Other things were normal including hematocrit, RBC, Vitamin D, DHEA.


I IMMEDIATELY halved my dose of both T and the HCG, and began to take Aromasin 10mg EOD. Since that time about 6 weeks ago I've been crashing and going downhill. This past week was the worst, no sex drive, and couldn't get hard during sex at all.


Last weekend I tested my bloods. March 2017.
T - 110th%
E - 75th%
SHBG - 0th%


The obvious question... how did my SHBG get so low?? I'm very confused and not sure what the next step should be. I'm feeling intense lethargy and the gym feels brutal at 50% through my workout. Not to mention I'd love to get some sex drive and all that good stuff back!


Much appreciate any thoughts, concerns, or ideas you may have.
 
Vince,

Thanks for chiming in. Here are results for January 2018 and last week, March 2018.

January 2018.
Free T 48.6 (4.7-24.4 ng/dL)
T 22.56 (.47 - 9.8 ng/ml)
E 44.01 (<39.8 pg/ml)
SHBG 62.8 (32.4-128 nmol/L)
DHEA-S 340.1 (80-560 ug/dL)
Prolactin 4.7 (2.1-17.7 ng/ml)

Resultant change in behavior:
Halve the Test dosage to 30g Test E EOD.

March 2018.
T 8.31 (1.6-7.5 ng/ml)
SHBG 27 (32.4-128 nmol/L)
E 28.6 (<39.8 pg/ml)

Resultant change in behavior:
Stop AI use.

Unsure of what to do next...
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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