Advice on Labs and Symptoms

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whipstein

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I began TRT ~3 months ago. I'm a 40yo. Started on the Androderm at 4mg/day. Started to feel a little better, but the patch would fall off as soon as I would start to sweat. Asked for shots, but my GP refuses to do shots. He put me on Androgel at 5mg/day. I actually started to feel a little worse. GP wanted to wait 2 months to redo bloodwork. I've basically felt like crap ever since the incident that spurred me to get checked happened.

I'm still feeling very fatigued. I've been sleeping like crap ever since I started TRT. I wake up very early. Some nights I wake up multiple times throughout the night. I've been suspecting there's something beyond the low T causing issues. Maybe the sleep thing is just stress, but I'm not sure. Would like to get your thoughts. My first suspicion was thyroid, due to having a very low temp, 96's to 97's throughout the day, and having a very low resting heartrate of low 40's to low 50's and feeling cold a lot. Also, even controlling my diet, if I gained any weight while weightlifting, the majority of it is fat. I have a very difficult time losing fat, which is almost entirely around my waist and butt. Also having intermittent feeling of depression. Mainly only happens when I feel very fatigued. Sometimes I will fall asleep on the couch after playing hockey for an hour in the morning.

Needless to say, I'm not going back to my GP, even though I've had him for 14 years. He has basically put me through hell trying to deal with this. He seems to have the opinion that I just want T so I can bulk up or something. I got him to refer me to and endo that handles a lot of TRT. I will have my first appointment in about 2 weeks. I just hope he can get me moving in the right direction.

Original Labs prompting TRT
Glucose 91mg/dL (70-99)
BUN 22mg/dL (9-23)
Creatinine 0.84mg/dL (0.7-1.3)
Na 140nmol/L (132-146)
K 4.3nmol/L (3.5-5.5)
Cl 104 nmol/L (99-109)
CO2 30nmol/L (20-31)
Calcium 9.3mg/dL (8.7-10.4)
TPROT 7.4g/dL (5.7-8.2)
Albumin 4g/dL (3.4-5)
Bilirubin 0.4mg/dL (0.3-1.2)
ALP 77U/L (45-129)
AST(SGOT) 20U/L (5-35)
ALT(SGPT) 19U/L (10-49)
Estradiol 19pg/mL (<40)
TSH 3.695uIU/mL (0.35-5.5)
SHBG 56nmol/L (17.3-65.8)
Testosterone 264ng/dL (241-827)
Test, Free 3.6ng/dL (6-27)
Hematocrit 42.7%

Labs after 2 months (prior to applying gel for day)
Testosterone 300ng/dL (241-827)
Test, Free 3.5ng/dL (6-27)
SHBG 69.2nmol/L (17.3-65.8)
TSH 1.69UIU/mL (0.35-5.5)
FT3 3.8pg/mL (2.3-4.2)
FT4 1.18ng/dL (0.89-1.76)
aTG <15IU/mL (<60)
TPO <28IU/mL (<60)

Labs I did myself about 2 weeks later (right after applying gel)
Total Iron 82mcg/dL (50-180)
Iron Binding Capacity 277mcg/dL (250-425)
%Saturation 30 (15-60)
Pregnenalone 65ng/dL (13-208)
aTG <1IU/mL (<=1)
TPO 14IU/mL (<9)
DHEA-S 138mcg/dL (106-464)
Ferritin 79ng/mL (20-380)
FSH 3.0mIU/mL (1.6-8)
LH 2.4mIU/mL (1.5-9.3)
Prolactin 5.9ng/mL (2-18)
Estradiol 27pg/mL (<=39)
Vit D 27ng/mL (30-100)
Testosterone 592ng/dL (250-1100)
Test, Free 91.1pg/mL (35-155)

Any thoughts on if these symptoms really are due to not addressing the T issue properly/stress. Or maybe something else? I did start supplementing with 6000IU of vitamin D based on the last labs.

Also, I never got checked for primary vs secondary, so ran FSH/LH and the numbers imply primary. Is that right?
 
Defy Medical TRT clinic doctor
Your FT3 is in the upper ref range, FT4 in the lower, which in a lot of cases indicates "pooling" (FT3 building, not getting into the cells). It would be helpful to run thyroid again, but add Reverse T3.
 
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Your FT3 is in the upper ref range, FT4 in the lower, which in a lot of cases indicates "pooling" (FT3 building, not getting into the cells). It would be helpful to run thyroid again, but add Reverse T3.

I've read about "pooling" in conjuction with adrenal fatigue. Is that what you are implying? Or is there some other mechanism that would cause a high RT3? I'm not really a believer in adrenal fatigue. To me it appears like these issues are due to stress. I can see myself being stressed out and causing something like this.

Again, symptoms suggest thyroid, but numbers refute it, except for TPO. I was also considering sleep apnea maybe? Have seen my BP going up some in conjunction with all of this. That would fit with the fatigue and sleepiness too. As you can see, I'm a little lost here due to the broad symptoms that don't point to anything exactly.
 
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