Accomplished Molecular Biologist Nadine Hornig Discusses Finasteride Syndrome

madman

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Nadine Hornig, PhD is Principal Investigator at the Institute for Human Genetics at University Medical Center Schleswig-Holstein and Kiel University. Dr. Hornig conducts research in the areas of molecular biology, genetics, epigenetics, and endocrinology and was recently published in the distinguished journal Nature for her paper, "Formin-mediated nuclear actin at androgen receptors promotes transcription." She is a member of PFS Network's scientific advisory board and lead researcher on the charity's current epigenetics study in Kiel.




00:00 Introduction
02:09 Overview on the androgen receptor
03:29 What is an androgen receptor cofactor
06:43 Problems with androgen receptor signaling
08:25 Why did Dr. Hornig decide to conduct research on post-finasteride syndrome
10:50 What techniques are being used in PFS Network's current epigenetics study
13:18 Why is analyzing samples of patient genital tissue sufficient
16:30 Why is the current epigenetics study a necessary groundwork
18:42 What is chromatin
20:44 What are possible outcomes of the current epigenetics study




Post-Finasteride Syndrome is the current term for a rare syndrome of devastating physical, neurological, and sexual side effects that persist and progress after stopping finasteride. The condition occurs primarily in younger men who have taken the drug to treat hair loss. There is currently no effective treatment for this disease.

PFS has a disastrous impact on patients, their families and their friends. It often causes disability, isolation and suicide. Every person is valuable, and everyone deserves to make a fully informed choice with their health.
 

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Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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