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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
45 Considering TRT: PCa History & Rate My Labs - Feedback Pls
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<blockquote data-quote="madman" data-source="post: 206678" data-attributes="member: 13851"><p>Much more involved than just having healthy T levels let alone other hormones as low libido let alone ED are multifactorial.</p><p></p><p>Need a more thorough set of labs.</p><p></p><p>Keep in mind that dysfunctional thyroid/adrenals can easily mimic low-t symptoms.</p><p></p><p>When were labs done?</p><p></p><p>Testing should be done in a fasted state between 7-10 am as we want to test at peak.</p><p></p><p>During the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase around 3-4 am reaching a peak between 6-8 am and by 11-12 pm will start to decline late afternoon/early evening reaching a trough between 6-8 pm.</p><p></p><p>Fluctuations from peak--->trough would be around 20-25%</p><p></p><p>Natural T levels follow a diurnal 24 hr circadian rhythm and will start to rise gradually around 3 am reaching peak levels around 8 am</p><p></p><p>Natural endogenous testosterone secretion is pulsatile and diurnal.</p><p></p><p>FT 5-10 ng/dL would be considered low.</p><p></p><p>FT 16-31 (high-end) ng/dL is healthy.</p><p></p><p>Most men on trt will do well with FT 20-30 ng/dL range.</p><p></p><p>Some men will <u>feel just fine</u> with a FT 15-20 ng/dL.</p><p></p><p>Comes down to the individual.</p><p></p><p></p><p>Although TT is important to know FT is what truly matters as it is the unbound active fraction of T responsible for the positive effects.</p><p></p><p>Your TT 536 ng/dL although not stellar is by no means low and more importantly, seeing as your SHBG is normal 35 nmol/L then your FT would be far from what would be considered low, and even then before jumping to any conclusions the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p></p><p></p><p></p><p><strong>My brother is a professional bodybuilder, fitness coach and preps for some globally known names. <u>He suggested I start TRT at the following protocol</u>:</strong></p><p><strong></strong></p><p><strong><u>75mg test cyp</u> 2x week</strong></p><p><strong><u>25 - 50mg masteron E </u>2x week</strong></p><p><strong>10-12 mg daily boron bisglycinate</strong></p><p></p><p></p><p>Hard to believe he would let you rely on supplementing with longjack (Eurycoma longifolia) all those years let alone throwing in drostanolone of the hop when you have no experience using exogenous T let alone have absolutely no idea how your body will react to a said dose of exogenous T.</p><p></p><p>Even then if there was a boost in T from the so-called T-boosters it would be transient and minimal at best!</p><p></p><p><strong>19. What is the evidence for herbal or natural testosterone “boosters” in treating TD?</strong></p><p><strong></strong></p><p><strong><em><u>Current evidence-based reviews of the most common ingredients in testosterone boosters (T-boosters) on the market have found minimal to no evidence demonstrating their efficacy</u>.40 Many of the ingredients within such compounds have never been tested for safety and/or efficacy in human trials. Among human trials, only 30% demonstrated an improvement in testosterone levels, 2% resulted in a decrease in testosterone, and 68% had either an indeterminant effect or no effect at all on testosterone levels.41 Concerningly, several case studies have demonstrated severe adverse events from T-boosters that contain banned/illicit substances, including steroids.42,43 Currently, T-boosters cannot be recommended by health practitioners and patients should be cautioned regarding the unknown efficacy and safety of T-boosters, along with the possibility for severe adverse events. Regulated, evidence-based treatments should be offered as an alternative in symptomatic hypogonadal men (moderate LE, strong recommendation).</em></strong></p><p></p><p>No point in jumping in on 150 mg T/week let alone adding in drostanolone which has no place in a standard trt protocol.</p><p></p><p>Supplementing boron will have no significant impact on T.</p><p></p><p>100 mg/week split (50 mg every 3.5 days) would be a good starting point.</p><p></p><p>With an SHBG 35 nmol/L, you would most likely achieve a healthy let alone high-end or in some cases absurdly high FT level.</p><p></p><p>Most men on trt are using 100-200 mg/week and even then most can easily achieve a healthy let alone very high FT on 100-150mg/week.</p><p></p><p>Sure some men may need the higher end dose to achieve such levels but it is far from common.</p><p></p><p>Standard 200mg/week protocol pushed by those run-of-the-mill T clinics let alone some doctors in the know.....sure if you are content with having absurdly high T level during the first 2-3 days of the week only to be followed by lower levels come weeks end and in most cases, trough levels at day 7 are still high for many and top it off that they all throw in an AI off the hop to control elevated estradiol!</p><p></p><p>Keep in mind that the metabolites<strong> <em>estradiol and</em></strong><em> <strong><em>DHT</em></strong></em> are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on mood, energy, libido, erectile function, cardiovascular/brain/bone/immune system health, body composition.</p><p></p><p><em><strong>*Testosterone drugs provide a <u>hormone identical to that already produced in the body, presenting the same spectrum of physical and physiological effects</u></strong></em><strong><em>. </em></strong></p><p></p><p>200 mg T/week whether split twice weekly (every 3.5 days), M/W/F, EOD, or daily would be overkill for most and have your trough FT levels through the roof.</p><p></p><p>Even then the best piece of advice is to start low and go slow using a T only protocol as we want to see how the body reacts to testosterone let alone where said protocol (dose T/injection frequency) will have your TT, FT, estradiol, SHBG and other blood markers such as CBC which includes (RBCs/hemoglobin/hematocrit).</p><p></p><p>The use of hCG can eventually be added if your main concern is maintaining fertility, minimizing/preventing testicular atrophy while using exogenous T.</p></blockquote><p></p>
[QUOTE="madman, post: 206678, member: 13851"] Much more involved than just having healthy T levels let alone other hormones as low libido let alone ED are multifactorial. Need a more thorough set of labs. Keep in mind that dysfunctional thyroid/adrenals can easily mimic low-t symptoms. When were labs done? Testing should be done in a fasted state between 7-10 am as we want to test at peak. During the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase around 3-4 am reaching a peak between 6-8 am and by 11-12 pm will start to decline late afternoon/early evening reaching a trough between 6-8 pm. Fluctuations from peak--->trough would be around 20-25% Natural T levels follow a diurnal 24 hr circadian rhythm and will start to rise gradually around 3 am reaching peak levels around 8 am Natural endogenous testosterone secretion is pulsatile and diurnal. FT 5-10 ng/dL would be considered low. FT 16-31 (high-end) ng/dL is healthy. Most men on trt will do well with FT 20-30 ng/dL range. Some men will [U]feel just fine[/U] with a FT 15-20 ng/dL. Comes down to the individual. Although TT is important to know FT is what truly matters as it is the unbound active fraction of T responsible for the positive effects. Your TT 536 ng/dL although not stellar is by no means low and more importantly, seeing as your SHBG is normal 35 nmol/L then your FT would be far from what would be considered low, and even then before jumping to any conclusions the only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). [B]My brother is a professional bodybuilder, fitness coach and preps for some globally known names. [U]He suggested I start TRT at the following protocol[/U]: [U]75mg test cyp[/U] 2x week [U]25 - 50mg masteron E [/U]2x week 10-12 mg daily boron bisglycinate[/B] Hard to believe he would let you rely on supplementing with longjack (Eurycoma longifolia) all those years let alone throwing in drostanolone of the hop when you have no experience using exogenous T let alone have absolutely no idea how your body will react to a said dose of exogenous T. Even then if there was a boost in T from the so-called T-boosters it would be transient and minimal at best! [B]19. What is the evidence for herbal or natural testosterone “boosters” in treating TD? [I][U]Current evidence-based reviews of the most common ingredients in testosterone boosters (T-boosters) on the market have found minimal to no evidence demonstrating their efficacy[/U].40 Many of the ingredients within such compounds have never been tested for safety and/or efficacy in human trials. Among human trials, only 30% demonstrated an improvement in testosterone levels, 2% resulted in a decrease in testosterone, and 68% had either an indeterminant effect or no effect at all on testosterone levels.41 Concerningly, several case studies have demonstrated severe adverse events from T-boosters that contain banned/illicit substances, including steroids.42,43 Currently, T-boosters cannot be recommended by health practitioners and patients should be cautioned regarding the unknown efficacy and safety of T-boosters, along with the possibility for severe adverse events. Regulated, evidence-based treatments should be offered as an alternative in symptomatic hypogonadal men (moderate LE, strong recommendation).[/I][/B] No point in jumping in on 150 mg T/week let alone adding in drostanolone which has no place in a standard trt protocol. Supplementing boron will have no significant impact on T. 100 mg/week split (50 mg every 3.5 days) would be a good starting point. With an SHBG 35 nmol/L, you would most likely achieve a healthy let alone high-end or in some cases absurdly high FT level. Most men on trt are using 100-200 mg/week and even then most can easily achieve a healthy let alone very high FT on 100-150mg/week. Sure some men may need the higher end dose to achieve such levels but it is far from common. Standard 200mg/week protocol pushed by those run-of-the-mill T clinics let alone some doctors in the know.....sure if you are content with having absurdly high T level during the first 2-3 days of the week only to be followed by lower levels come weeks end and in most cases, trough levels at day 7 are still high for many and top it off that they all throw in an AI off the hop to control elevated estradiol! Keep in mind that the metabolites[B] [I]estradiol and[/I][/B][I] [B][I]DHT[/I][/B][/I] are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on mood, energy, libido, erectile function, cardiovascular/brain/bone/immune system health, body composition. [I][B]*Testosterone drugs provide a [U]hormone identical to that already produced in the body, presenting the same spectrum of physical and physiological effects[/U][/B][/I][B][I]. [/I][/B] 200 mg T/week whether split twice weekly (every 3.5 days), M/W/F, EOD, or daily would be overkill for most and have your trough FT levels through the roof. Even then the best piece of advice is to start low and go slow using a T only protocol as we want to see how the body reacts to testosterone let alone where said protocol (dose T/injection frequency) will have your TT, FT, estradiol, SHBG and other blood markers such as CBC which includes (RBCs/hemoglobin/hematocrit). The use of hCG can eventually be added if your main concern is maintaining fertility, minimizing/preventing testicular atrophy while using exogenous T. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
45 Considering TRT: PCa History & Rate My Labs - Feedback Pls
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