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Mental Health
1st ketamine treatment for depression
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<blockquote data-quote="madman" data-source="post: 119517" data-attributes="member: 13851"><p><span style="font-size: 26px"><strong>Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability</strong></span></p><p></p><p></p><p>Conclusions and future directions </p><p></p><p>The discovery of ketamine’s rapid antidepressant effects has invigorated the field of psychiatry and given hope to millions of patients and caretakers. However, little is known about the long-term effects of repeated exposure to ketamine, and the addiction field has demonstrated that the neurobiological effects of acute vs chronic ketamine result in very different molecular profiles. A question clinicians may have is: where is the threshold at which the benefits of therapeutic, antidepressant ketamine become overshadowed by its risk of addiction? As women are twice as likely to develop depression and progress through the stages of addiction faster than men, are they at an increased risk? Preclinical literature reviewed therein suggests that female rats are more sensitive to ketamine’s effects, but more research is needed in preclinical and clinical studies to fully understand sub-anesthetic ketamine.</p></blockquote><p></p>
[QUOTE="madman, post: 119517, member: 13851"] [SIZE=26px][B]Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability[/B][/SIZE] Conclusions and future directions The discovery of ketamine’s rapid antidepressant effects has invigorated the field of psychiatry and given hope to millions of patients and caretakers. However, little is known about the long-term effects of repeated exposure to ketamine, and the addiction field has demonstrated that the neurobiological effects of acute vs chronic ketamine result in very different molecular profiles. A question clinicians may have is: where is the threshold at which the benefits of therapeutic, antidepressant ketamine become overshadowed by its risk of addiction? As women are twice as likely to develop depression and progress through the stages of addiction faster than men, are they at an increased risk? Preclinical literature reviewed therein suggests that female rats are more sensitive to ketamine’s effects, but more research is needed in preclinical and clinical studies to fully understand sub-anesthetic ketamine. [/QUOTE]
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Mental Health
1st ketamine treatment for depression
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