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“Sweet spot E2” vs test levels
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<blockquote data-quote="madman" data-source="post: 140467" data-attributes="member: 13851"><p>As we know most concern themselves with TT numbers when FT is what truly matters as it is the unbound active fraction of testosterone responsible for the positive effects.</p><p></p><p>The FT bioactive fraction of testosterone is 2-3% and most men need their FT 2-3% of TT in order to experience relief/improvements of low t symptoms.</p><p></p><p>What dose of T one needs to achieve a healthy level of FT( 2-3%) comes down to ones SHBG levels and individual differences in genetics, sensitivity of the AR (androgren receptor), polymorphism of the AR and CAG repeat length.</p><p></p><p>Regarding FT levels depending on the above factors some men will do well with a TT in the 600-800 ng/dL of the physiological range as oppose to others who do better with a TT at the higher end or above the physiological range 1200+ and above.</p><p></p><p>Of course there are men with very high SHBG or men (older men and former steroid abusers) with AR resistance who may need to run a higher TT well into the supra-physiological range 1500+ in order to overcome the resistance and achieve a healthy FT.</p><p></p><p>Trt doses commonly prescribed are usually 100-150 mg/week and in some cases 200 (not as common) and 200+ in others (rare).</p><p></p><p>In your situation it depends on what TT/FT level you are achieving on 150 mg/week.</p><p></p><p>200 mg/week for many men would put their T levels well into the supra-physiological range but again SHBG is going to play a big role on what FT level is achieved at such dose.</p><p></p><p>By all means if you feel well overall on 150 mg/week but as you say feel better on 250 mg/week so be it <strong><span style="color: rgb(184, 49, 47)">as long as your blood work is healthy I see no issues </span></strong>but what TT/FT level are you hitting on 250 mg/week as for most 250mg/week is basically a low steroid dose and well beyond needed for trt.</p><p></p><p>The purpose of trt is to replace physiological levels of testosterone in order to experience relief/improvement of low t symptoms and to improve ones physical/mental wellbeing.</p><p></p><p>One has to draw a line when we use the word feel best as one can feel good at 200 mg/week, better at 250+ and so on.</p><p></p><p>Majority of low T symptoms regarding areas such as energy/mood/libido/erectile function/body composition/physical recovery are usually achieved when hormones are in a healthy range.</p><p></p><p>Excess T as in very high supra-physiological levels 2000+ is in no way needed to achieve relief/improvement of low T symptoms and the only true benefit to running such high levels would be for the sole purpose of gaining muscle/strength.</p><p></p><p></p><p>Again sure there are men who need 200 mg/week or possibly slightly higher but 250mg/week would be a low dose steroid cycle for most and when using testosterone/AAS for the sole purpose of muscle enhancement 250-500 mg/week is the range where many start.</p><p></p><p>My SHBG is 30 nmol/L just under mid-range (10-60 nmol/L) and I inject 150 mg/week (75 mg every 3.5 days).....my TT trough on average 1200-1300 ng/dL and my FT is double the top end of the range.</p><p></p><p>Overall I feel great and have been on the same protocol for 2 years.....no a.i. or hcg use.</p></blockquote><p></p>
[QUOTE="madman, post: 140467, member: 13851"] As we know most concern themselves with TT numbers when FT is what truly matters as it is the unbound active fraction of testosterone responsible for the positive effects. The FT bioactive fraction of testosterone is 2-3% and most men need their FT 2-3% of TT in order to experience relief/improvements of low t symptoms. What dose of T one needs to achieve a healthy level of FT( 2-3%) comes down to ones SHBG levels and individual differences in genetics, sensitivity of the AR (androgren receptor), polymorphism of the AR and CAG repeat length. Regarding FT levels depending on the above factors some men will do well with a TT in the 600-800 ng/dL of the physiological range as oppose to others who do better with a TT at the higher end or above the physiological range 1200+ and above. Of course there are men with very high SHBG or men (older men and former steroid abusers) with AR resistance who may need to run a higher TT well into the supra-physiological range 1500+ in order to overcome the resistance and achieve a healthy FT. Trt doses commonly prescribed are usually 100-150 mg/week and in some cases 200 (not as common) and 200+ in others (rare). In your situation it depends on what TT/FT level you are achieving on 150 mg/week. 200 mg/week for many men would put their T levels well into the supra-physiological range but again SHBG is going to play a big role on what FT level is achieved at such dose. By all means if you feel well overall on 150 mg/week but as you say feel better on 250 mg/week so be it [B][COLOR=rgb(184, 49, 47)]as long as your blood work is healthy I see no issues [/COLOR][/B]but what TT/FT level are you hitting on 250 mg/week as for most 250mg/week is basically a low steroid dose and well beyond needed for trt. The purpose of trt is to replace physiological levels of testosterone in order to experience relief/improvement of low t symptoms and to improve ones physical/mental wellbeing. One has to draw a line when we use the word feel best as one can feel good at 200 mg/week, better at 250+ and so on. Majority of low T symptoms regarding areas such as energy/mood/libido/erectile function/body composition/physical recovery are usually achieved when hormones are in a healthy range. Excess T as in very high supra-physiological levels 2000+ is in no way needed to achieve relief/improvement of low T symptoms and the only true benefit to running such high levels would be for the sole purpose of gaining muscle/strength. Again sure there are men who need 200 mg/week or possibly slightly higher but 250mg/week would be a low dose steroid cycle for most and when using testosterone/AAS for the sole purpose of muscle enhancement 250-500 mg/week is the range where many start. My SHBG is 30 nmol/L just under mid-range (10-60 nmol/L) and I inject 150 mg/week (75 mg every 3.5 days).....my TT trough on average 1200-1300 ng/dL and my FT is double the top end of the range. Overall I feel great and have been on the same protocol for 2 years.....no a.i. or hcg use. [/QUOTE]
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“Sweet spot E2” vs test levels
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