tth

  1. madman

    Testosterone Recovery Dynamics After Short-Term ADT for Localized Prostate Cancer

    * Dr. Tombal recommends relugolix, an oral GnRH antagonist that restores normal testosterone within 90 to 120 days, when ADT is required, and notes that patients who fail to recover normal testosterone have worse prognosis. * He also supports testosterone supplementation in symptomatic...
  2. madman

    The Death of the ‘Testosterone Causes Prostate Cancer’ Myth: What Every Man on HRT Needs to Know

    Great presentation by the leading expert in the field! Abraham Morgentaler For 80 years the question has been: Wrong question The right question: Conclusions
  3. madman

    TRT After Prostate Cancer: Is Testosterone Therapy Safe for Hypogonadal Men?

    Reframing risk
  4. madman

    The Game-Changer: Oral Testosterone Pills Now Available at Urology Associates

    https://www.denverurology.com/urology-blog/oral-testosterone/ New, Oral Testosterone Now, we have oral testosterone available in pill format. wasn’t a viable option due to liver toxicity risks with older formulations. That’s why, for decades, doctors avoided prescribing pills and stuck to...
  5. madman

    Reimagining Testosterone Therapy: KYZATREX® (Oral TU)

    * We discuss KYZATREX, a cutting-edge oral therapy that employs lymphatic absorption to preserve liver health and supports fertility, making it ideal for younger men. We also examine its ability to maintain hormone balance without the need for aromatase inhibitors Shalin Shah is a...
  6. madman

    Dynamic landscape of therapeutic options for T deficiency in reproductive-aged males and their impact on suppression of the HPG-axis

    Most up to date paper! As usual Nelson house is where its at! Exogenous T formulations impact on suppression of the HPG axis. Here is a quick breakdown from most--->least suppressive! As we have stated numerous times on the forum ultra short-acting Natesto is where its at! Table 1 |...
  7. madman

    Oral TU (Kyzatrex) - Breakfast + Lunch Dosing Protocol/PKs

    * Just to be clear when it comes to the Breakfast + Lunch Dosing Protocol/PK as Dr. Sun stated: and although this is obviously not real pharmacokinetics I just basically superimposed the two graphs on eacth other and I think that this is roughly what's happening because I've checked labs on...
  8. madman

    New Data from Marius Pharmaceuticals Reveals High Prevalence of Low Libido, Energy and Quality of Life in Men

    https://www.globenewswire.com/news-release/2024/11/14/2981318/0/en/New-Data-from-Marius-Pharmaceuticals-Reveals-High-Prevalence-of-Low-Libido-Energy-and-Quality-of-Life-in-Men.html RALEIGH, N.C., Nov. 14, 2024 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a pharmaceutical company focused on...
  9. madman

    The Testosterone Project

    https://testosteroneproject.com/about/ https://www.globenewswire.com/news-release/2024/11/15/2982094/0/en/The-Testosterone-Project-Launches-on-National-Testosterone-Awareness-Day-November-17.html RALEIGH, N.C., Nov. 15, 2024 (GLOBE NEWSWIRE) -- The Testosterone Project, a new nonprofit...
  10. madman

    The Promise and Challenges of Oral Testosterone Therapy

    In recent years, the landscape of testosterone replacement therapy (TRT) has evolved significantly, offering new hope for hypogonadal men seeking effective and convenient treatment options. The introduction of oral testosterone undecanoate (TU) marks a pivotal advancement in this field, as...
  11. madman

    Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review

    Introduction Background and significance Hypogonadism, characterized by low testosterone levels, is a significant clinical condition affecting a substantial proportion of the male population, particularly older men. The management of hypogonadism often involves testosterone replacement therapy...
  12. madman

    Lipocine Announces Distribution and License Agreement with SPC Korea to Commercialize TLANDO® in South Korea

    https://www.prnewswire.com/news-releases/lipocine-announces-distribution-and-license-agreement-with-spc-korea-to-commercialize-tlando-in-south-korea-302292252.html SALT LAKE CITY, Oct. 31, 2024 /PRNewswire/ -- Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company leveraging its proprietary...
  13. madman

    52 Week Study of Safety, PK, & Efficacy of XYOSTED® for T Replacement in Male Adolescents with Hypogonadism

    Looking forward to this one! https://clinicaltrials.gov/study/NCT06689085 Brief Summary This is a 52-week open label single arm study to investigate the effects of XYOSTED, as testosterone replacement therapy, on adolescent males with either primary or secondary hypogonadism. The study...
  14. madman

    Redefining Medicine With Dr. Mohit Khera

    The MOpro LOL! * 50 mg T sub-q Sun/Thurs *10:58-13:21 (secondary polycythemia) Ahead of the highly anticipated A4M BHRT Symposium in Los Angeles, esteemed host of the Redefining Medicine podcast, Dr. Erika Schwartz, sat down with Dr. Mohit Khera, a specialist in male and female sexual...
  15. madman

    Age-stratified reference ranges for directly measured (ED LC-MS/MS) serum free testosterone in healthy men

    Just to be clear up any confusion this is Fiers camps data for mFT reference ranges not the harmonized reference range being worked on by the CDC. *Serum samples were analyzed from healthy men participating in the SIBLOS/SIBEX and EMAS studies, both population-based cohort studies * mFT...
  16. madman

    ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN

    INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels <300 ng/dL. Negative effects associated with hypogonadism include development of metabolic syndrome, increased risk of coronary artery disease, decreased libido, low bone mineral...
  17. madman

    Association between TRT and cardiovascular outcomes

    ABSTRACT Background The Cardiovascular safety of testosterone replacement therapy (TRT) among men with hypogonadism is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients receiving testosterone therapy by using all recently...
  18. madman

    LDS insulin syringe with a thin wall needle for injecting T strictly sub-q

    Currently using the BD 1mL 30G x 8mm for injecting strictly sub-q! No issues drawing/injecting .75 ml (75 units) twice-weekly with Depo-Testosterone (testosterone cypionate) which uses cottonseed oil as the carrier. Would be primo for drawing/injecting low volumes of the oily solution strictly...
  19. madman

    Testosterone recovery after ADT in localised prostate cancer

    Background and purpose To determine the rate and time of testosterone (T) recovery in patients (pts) with localised prostate cancer treated with radiotherapy plus 0-, 6-, 18- or 36-month of androgen deprivation therapy (ADT).Materials and methods In 1230 pts with prostate cancer randomised into...
  20. madman

    Cardiovascular safety of testosterone replacement therapy in men

    Abstract Introduction The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. Recent data suggested a TRT-related increased risk of atrial fibrillation (AF). To systematic review and meta-analyze CV risk related to TRT as derived from placebo...
  21. madman

    Dr. Morgentaler - debunking myths and misconceptions surrounding testosterone

    https://kellycaspersonmd.com/testosterone-with-dr-morgentaler/ Dr. Morgentaler, an expert in testosterone therapy, joins the podcast to debunk myths and misconceptions surrounding testosterone. He discusses the importance of testosterone beyond sex, challenges gender bias and stereotypes, and...
  22. madman

    How DHT and Androgens Drive Acne Formation

    Androgens are a key factor in acne pathogenesis. Lawrence Green, MD, FAAD discusses how hormones help drive the skin disease. How DHT and Androgens Drive Acne Formation Androgens are integrally associated with acne development. Acne originates in the sebaceous gland, which is under androgen...
  23. madman

    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    Today we’re excited to announce a breakthrough in men’s hormone optimization: Maximus' Oral TRT+ Protocol. Testosterone, without injections or messy creams, all while maintaining fertility markers. Timestamps: 0:00 - 0:09 - Introduction 0:10 - 3:54 - What is Maximus Oral TRT+? 3:55 - 4:44 -...
  24. madman

    Testosterone Replacement Therapy in Orthopaedic Surgery

    ABSTRACT Testosterone replacement therapy (TRT) is an indicated treatment of several medical conditions including late-onset hypogonadism,congenital syndromes, and gender affirmation hormonal therapy.Increasing population age, medical benefits, and public awareness of TRT have resulted in...
  25. madman

    Navigating hCG and Clomid: A Man's Guide to Preserving Reproductive Health

    Fertility *36:33-38:58 - coming off testosterone (clomid or clomid 25-50 mg daily + hCG 2000 IU M/W/F) *38:58-44:24 - staying on testosterone (T + hCG) *44:24-46:59 - (clomid + T) *47:00-50:31 - Long-term safety data (clomid/hCG) *50:31-58:25 - AI (aromatase inhibitors) Join urologists...
  26. madman

    High Testosterone Blood Levels May Increase Mortality

    https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.281/7600971 Abstract Introduction The benefits and risks of testosterone therapy (TT) have been a subject of long-standing debate. The recent TRAVERSE trial demonstrated that men who received TT did not show an increased risk of...
  27. madman

    Evaluation of Androgen Receptor Signaling and Saturation in ED

    https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.238/7600649 Abstract Introduction Testosterone (T) is a steroid hormone responsible for the development and maintenance of male secondary sex characteristics. T exerts this physiologic function throughout by binding to the androgen...
  28. madman

    Safety and Efficacy of Enclomiphene Compared to Clomiphene in Men with Low Testosterone

    *Our findings show that enclomiphene provides the same magnitude of improvement in testosterone but through safer means, as noted by its lower rate of documented adverse events *Further research and larger studies are warranted to validate these conclusions and explore additional long-term...
  29. madman

    Impact of TRT on Adverse Cardiovascular Events in Men with Low Testostosterone: Evaluation of Physiological and Supraphysiological T Levels

    https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.084/7600775 Abstract Introduction Sustained treatment with elevated levels of exogenous testosterone (T) has been linked to various adverse events, particularly concerning cardiovascular risks. However, there is currently a lack of...
  30. madman

    The Modulating Effects of FSH and Clomid on Men with Azoospermia or Oligozoospermia Taking hCG

    *Those taking hCG with FSH experienced a greater improvement in both testosterone and total sperm counts compared to men on hCG and Clomid *Moreover, these data suggest that hCG with FSH results in a more rapid improvement in both spermatogenesis and serum testosterone than historically...
  31. madman

    Subcutaneous Testosterone Pellet Implantation Procedure for Treatment of Low Testosterone

    The patient is placed in the lateral jackknife or fetal position. Implantation occurs in the upper outer quadrant of the posterior gluteal region. The skin is marked 3 cm below the halfway mark between the iliac crest and sacroiliac joint in a 10-cm line parallel to the femur. Hibiclens...
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