supraphysiological

  1. P

    Supraphysiologic testosterone (350 mg weekly)

    "Conclusion While 10–12 weeks of supraphysiologic testosterone reliably suppresses endogenous LH, FSH, and testosterone secretion, current high‑quality trials demonstrate full recovery of hormone levels within 3–6 months in healthy men, with no permanent disruption observed in these controlled...
  2. C

    High testosterone is like … finasteride? Say what!

    It’s not quite as off-the-wall as it sounds. We know that as serum testosterone increases the 5α-reductase enzyme starts to saturate, leading to a reduced efficiency in DHT creation, illustrated thusly: Even so, with high testosterone a lack of DHT is not going to be a problem; there’s still...
  3. Sergel

    Wonder what you guys think of this video...

    In this video, dr claims that we should be supraphysiologic ... like Free T in the 30 to 60 ng/dl ... darn, that is a total t between 1000 and 2000 ... like mostly in the high range... I currently have a free T of 15.5 and my doc wants me to reduce it! ...
  4. Seagal

    Supra physiological FT

    Dr Keith Nichols explains Why You May Need Supraphysiological Testosterone Levels.
  5. L

    TRT to Supraphysiological Levels for Body Building

    Hi All, I'm a male, 32, with normal/solid levels of testosterone (650 ng/dl TT). I've been exercising on and off since I was a teenager but have only been on a proper weightlifting and diet protocol for the past 6 months with a professional bodybuilder with my main goal being to obtain a great...
  6. A

    I feel best on a protocol that puts me above range... advice?

    So ive tried a few dosing protocols and have a journal where I log the side effects after 6-12 weeks. 20mg eod puts me at Total Testosterone 830 ng/dl (250-1100) Free Testosterone (151 pg/mL (35.0-155.0) Sensitive Estradiol 27 pgmL (< or = 29) I feel flat and low energy.. also irritable...
  7. T

    Question about supraphysiological dosages of testosterone

    In a January 2012 article, Dr. Mark Gordon discussed supraphysiological dosing: "Gordon explains that conventional medical dosage for testosterone is at 200-300 milligrams per week, which he has shown is far too high! "For example, a typical 25-35-year-old male naturally generates 4-10...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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