gnrh

Why is it a bad idea to take clomid/gonadorelin while on TRT?

I have read in this and other forums that taking clomid, gonadorelin, or kisspeptin while on TRT is a waste - that those things are used more for PCT, to regain testicular function. But why is it wasteful, or even contraindicated, to use those medications while on TRT? How does one harm the...
- phalloguy100
- Thread
- Sep 21, 2024
- clomephene clomid gnrh gonadorelin kisspeptin testicular atrophy trt
- Replies: 9
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
J
Which "part" of the HPTA is the hardest to "turn on" during PCT?

I am getting off testosterone after two years (if you want back story, you can read my previous posts, and I'm unable to perform any conventional PCT as I cannot tolerate SERMs. I have, however, been entertaining the idea of using GnRH or hCG as a way to "prime" the body before coming off TRT...
- JustPanicNoDisco
- Thread
- Oct 2, 2022
- cold turkey gnrh hcg pct
- Replies: 4
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
C
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

TL;DR: Over a period of seven weeks, treatment with GnRH and enclomiphene raised LH and FSH from around 0.1 mIU/mL to about 1.0 mIU/mL, even though TRT and hCG dosing were continued. Subjective results have been encouraging. I had written previously on the subject of GnRH suppression on TRT...
- Cataceous
- Thread
- Apr 10, 2020
- enclomiphene fertility gnrh lh pct pituitary restart
- Replies: 82
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
C
Is GnRH suppression hurting us?

Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril. TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH...
- Cataceous
- Thread
- Jan 26, 2020
- gnrh hpta suppression
- Replies: 63
- Forum: Testosterone Side Effect Management
Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study.

Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Rastrelli G, Corona G, Mannucci E, Maggi M. Andrology. 1 OCT 2014 A meta-analysis was performed to systematically analyse the results of gonadotropin and GnRH therapy in inducing spermatogenesis...
- Nelson Vergel
- Thread
- Oct 1, 2014
- Replies: 0
- Forum: Testosterone and Men's Health Articles

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038