genetics

Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16612 Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are promising...
- Seagal
- Thread
- Jul 24, 2025
- genetics glp-1
- Replies: 0
- Forum: Weight Loss Options
Functional neuronal circuits emerge in the absence of developmental activity

https://www.nature.com/articles/s41467-023-44681-2 https://www.psypost.org/neuroscience-harvard-scientists-just-revealed-a-remarkable-fact-about-brain-development/ “In the age-old question of nature versus nurture, we land decisively on the side of nature,” Barabási told PsyPost. “We challenge...
- Seagal
- Thread
- Feb 23, 2024
- brain behavior genetics
- Replies: 0
- Forum: Mental Health
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Effect of genetics on male secondary sex characteristics vs Low T

Hi all, Wondering how much genetics plays a role in secondary sex characteristics vs total testosterone levels. I read a paper (attached) which shows that professional athletes have testosterone levels around 500-600ng/dl, which is around my levels but i have very poor secondary sex...
- Welshlad87
- Thread
- Jun 5, 2023
- genetics genetics vs. low t low testoserone receptors shbg trt
- Replies: 3
- Forum: Testosterone Basics & Questions
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HCT Management

Nothing new per se but it's a nice summary. Also ventures into genetic predispositions. https://selfhacked.com/blog/hematocrit/
- TestOneTwo
- Thread
- Jun 29, 2020
- genetics hct hematocrit
- Replies: 0
- Forum: Testosterone Side Effect Management
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Genetic architecture of human thinness compared to severe obesity

Genetic architecture of human thinness compared to severe obesity
- Tommy Wall
- Thread
- Feb 3, 2019
- genetics
- Replies: 4
- Forum: Health & Wellness
Another study proves that genetic factors make some men more prone to TRT side effect

Several studies have been published on the subject of genetic predisposition to certain side effects of testosterone. Here is the latest The role of the androgen receptor CAG repeat polymorphism and other factors which affect the clinical response to testosterone replacement in metabolic...
- Nelson Vergel
- Thread
- Oct 29, 2013
- Replies: 0
- Forum: Testosterone and Men's Health Articles

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038