Ar

* Chronic exposure to supraphysiologic doses of AAS induces a variety of pathophysiological changes in the cardiovascular system. The mechanisms are multifactorial, involving direct androgen receptor-mediated effects on cardiac and vascular tissues as well as indirect metabolic and hemodynamic...

Again would tread lightly on how high you run your trough/steady-state FT level! This can easily backfire in the long-run for many especially when it comes to mood, libido and erectile function! Too high a FT level can be just as bad in many ways as having too low a FT level. Libido starts in...

Abstract Testosterone, the main endogenous active androgen, is used to treat many clinical conditions, such as hypogonadism, infertility, erectile dysfunction, osteoporosis, anemia, and in transgender therapy (female-to-male transsexuals). Androgens are also used by athletes to enhance...

https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.238/7600649 Abstract Introduction Testosterone (T) is a steroid hormone responsible for the development and maintenance of male secondary sex characteristics. T exerts this physiologic function throughout by binding to the androgen...

Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer (2023) Samuel R. Denmeade*,Laura A. Sena, Hao Wang, Emmanuel S. Antonarakis, Mark C. Markowski Abstract Inhibition of androgen receptor (AR) signaling has been the mainstay of treatment...

The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications (2022) Rajendra Kumar, Laura A. Sena, Samuel R. Denmeade & Sushant Kachhap Abstract The discovery of the benefits of castration for prostate cancer treatment in 1941 led to androgen...