acne; pathophysiology; treatment; sebum

A Roadmap for Clear Skin: Pathways to Put Acne in the Rearview Mirror

This ones going out to all those bros stinkin' up those so called HRT/men's health forums! Stop f**king blaming high estradiol! Critical points here! * The four established pillars of acne pathogenesis are sebum production, follicular hyperkeratinization, Cutibacterium acne (C. acnes)...
- madman
- Thread
- Mar 29, 2025
- acne; pathophysiology; treatment; sebum
- Replies: 3
- Forum: Testosterone Side Effect Management
The primary role of sebum in the pathophysiology of acne vulgaris

ABSTRACT Background Sebum physiology and its contributions to acne vulgaris (AV) pathophysiology have been long debated. Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene...
- madman
- Thread
- Dec 26, 2023
- acne; pathophysiology; treatment; sebum
- Replies: 9
- Forum: Testosterone Side Effect Management

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038