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There is no shutdown happening because MK677 just promotes more endogenous GH release. Taking it before bed can help with some side effects but the half life (24 hours) is too long for this to prevent day time fatigue.

MK677 is a ghrelin mimetic. It’s well-known to increase hunger. So much so that many bodybuilders rely on it when bulking to increase their appetite.

Because you get all the nasty side effects of MK677 like: 1) Ravenous hunger 2) Excessive daytime lethargy 3) Excessive water retention

MK-677 is a joke. Anyone who wants the benefits of this compound without the ravenous hunger would use CJC and Ipamorelin instead.

My antibodies were almost high (very top end of the reference range) and I have a lump on the right side of my throat. Today I started 100 mcg T4 and 50 mcg T3 Haven’t felt anything different so far but I’ll give it time.

Also in terms of iodine, I eat a lot of seaweed (I know, I’m weird). That supposedly rich in iodine. I also have a kelp supplement I take once in the morning.

Diet consists of lots of veggies, lean protein, and moderate-low amounts of fat (I have some heartburn issues at the moment that’s preventing me from eating more fat) Thyroid antibodies were 1.0 IU/mL for thyroglobulin antibody test (ref range 0.0-0.9) so this is HIGH. Thyroid peroxidase...

Please help me understand my blood work and symptoms I’ve been struggling for the longest time with fatigue, stubborn weight, and feeling extremely cold + sluggish, constipated and having ED. I’ve been taking my oral temperature on waking and throughout the day. Waking temp ranges from 92-96...

Also forgot to mention: I’ve been dealing with some thyroid issues. Waking body temperature has been 93-94 Fahrenheit with a maximum daily temperature of 96.6. Labs showed TSH of 1.1, T4 was normal at 4.6, but free T3 was low. I suspected high RT3 so I ordered a new set of labs of TSH/Free T4...

I’ve been struggling with low E2 for the longest time. Started off my TRT 36 mg daily test CYP, 200 IU HCG daily, and 0.0625 mg anastrozole twice per week. Dropped the AI due to low E2 symptoms (mostly achy knees, lethargy, difficulty maintaining/getting erection). Bloodwork showed T = 3100...

Agreed. I think being hypogonadal for 2.5 years has just made me overly anxious/reactive. I’m doing 30 mg test C EOD for 105 mg per week.

I had stopped the HCG. Fearing crashed E2, I used 200 IU. You can clearly tell I’m a mess lol. I tossed my AI and HCG in the trash. No temptation to keep dallying.

I was feeling pretty great this morning but then suddenly got hit with a wave of fatigue. Did my injection this morning but it wouldn’t have even peaked yet. Thinking HCG might be the problem. I’m cutting out everything but test on an EOD schedule for now.

Hi Systemlord, Quick update: I didn’t inject any testosterone yesterday. Only 200 IU HCG. I felt much better. My sleeping heart rate went down from 53 bpm to 49 bpm. Is it possible I’m just allergic to the carrier oil?

Old protocol was 200 mg split into daily administrations with 250 IU HCG EOD Bloodwork revealed elevated RBC (6.20 million/uL), normal hematocrit (43.4) and low Hemoglobin (13.0). I expected my hemoglobin to be low because I have beta thalassemia trait. Pre-TRT my hemoglobin was 10.0 and my RBC...

Interesting… For me personally, running 200 IU HCG ED and 50 mg Pregnenolone raised my progesterone way too high. I dropped the Pregnenolone and now I’m waiting to see where my progesterone falls. I think high progesterone can cause ED/Lethargy which I was experiencing a fair bit of.

Hey Vince. This may be a bit off-topic but I was curious to hear if you've experimented with different HCG protocols and what worked best for you.

Melatonin is some interesting stuff. It also raises growth hormone, seems to increase prolactin, inhibits GnRH release, etc. It also seems to lower dopamine (presumably because it lowers prolactin) Me personally, I can’t do more than 4-5 mg of melatonin. Otherwise I’m too drowsy and...

This study (Melatonin blocks the activation of estrogen receptor for DNA binding - PubMed) seems to show that melatonin hinders the action of estrogen-bound estrogen receptors. "The present study shows that melatonin prevents, within the first cell cycle, the estradiol-induced growth of...

Yeah they’re different. Gonadorelin is GnRH and stimulates release of LH and FSH from your pituitary. For me personally, Gonadorelin works because I inject it at least 3x per day with a minimum of 2 hours between injections of 20 mcg.

I'll also add that men using HCG should be EXTREMELY CAREFUL about adding in pregnenolone. For me personally, even 600 IU of HCG per week puts my progesterone over the reference range. For this reason, I decided to cut out HCG and I'm now using Gonadorelin which is working much better for me.

It's probably from your progesterone going up. Be careful. Too high of a progesterone can cause ED and lethargy.

I agree that trial and error is probably the best course of action. Start low and see how it affects. It blows my mind though that clinics offer Deca rather than NPP. NPP has a considerably shorter half life so if shit goes south you can bail rather quickly. With deca you're gonna be sitting...

Human equivalent dose would be 0.81 mg/Kg which is VERY LOW

In rats, administration of nandrolone resulted in reduced dopaminergic and serotonergic transmission in the brain in response to the administration of cocaine for a period lasting from 5-6 times the duration of administration. If you look at anecdotal reports on the Steroids subreddit, we see...

I caution any and all men using Nandrolone to get cardiac imaging done. Nandrolone is well known to induce left ventricular hypertrophy. It is a very potent anabolic substance. Also, please keep in mind that the metabolites of nandrolone will linger in your body for up to 18 months. That means...

Bullshit. What you guys don't realize is that there is a huge variance in 1) Aromatase enzyme activity, 2) Estrogen receptor density and 3) Sensitivity to estrogen. The same thing goes with testosterone. Why is it that IFBB pros explode and get ABSOLUTELY MASSIVE on comparatively low-dose...

Update: It was caused by HCG. Removed HCG from my protocol as well as the AI and I've regained my libido and the finger swelling and hand numbness has completely gone away.

Also, do you guys have any knowledge on what sorts of side effects can result from high progesterone levels? Mine came back at 1.9

I’m going to cut out HCG for 2 weeks and evaluate

For the past week or so I've been experiencing some notable swelling in my fingers when I lay down to sleep at night. It gets bad enough to where I wake up at night because my right hand is totally numb and then I have to awkwardly shift sleeping position. My protocol is currently 20 mg test C...