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On top of that, this dubious "research" was paid by Palatin Technologies, the manufacturer of Vyleesi® (bremelanotide injection). Not trustworthy to me. Seems like the article is just disguised marketing.

The relevant question is what percent of the patients remained on bremelanotide for longer than 6 months, instead of switching to viagra/cialis/levitra. Over 46 months, only 444 dispenses of bremelanotide? That is like 10 dispences/month. Doesn't seem much for a sexual health clinic. 73% of the...

Stress can provoke ulcers but is unavoidable response to financial difficulties. It won't stop until you find a job with more financial security. Don't forget you can try intestinal anti-inflammatories like Smecta or Pepto-Bismol. The antibiotic Rifaximin that I suggested is unique because it's...

You can do another stool test for H. Pylori to see if it's eradicated. This is usually done at least 1 month after the last antibiotic pill, to give it time to proliferate and be detected by the test. The fact you pain is gone for a month after antibiotics, suggests infectious origin. It may be...

Did you go to a gastroenterologist to do all the testing for inflammatory bowel diseases, intestinal infections, gastritis, colitis, upper endoscopy and colonoscopy? If low DHEA is involved in your intestinal pain, popping a DHEA pill should resolve it. Or it may cover it up, because DHEA may...

If you have chronic abdominal pain, the logical thing is to investigate your digestive tract. It may be a time coincidence the pain started when you were taking trenbolone. Not everything is about hormones. A good intestinal anti-inflammatory is 5g (teaspoon) L-Glutamine in a cup of water. You...

It seems to be acting on GABA, like benzos. Unlikely to be drastically different in effects and side effects.

I am surprised that at such a relatively high TRT dose, the RBC, Hemoglobin, and Hematocrit are not higher? I think 8 weeks on such TRT is enough time for these parameters to rise. Could it be the lack of carbs?

The AI by itself does increase the free T by reducing T conversion to E. The role of DHEA is not clear because it doesn't increase T in men, it converts to E mostly, which shouldn't be affected by the AI because it does not work directly on E. The effects of AI or DHEA on other hormones or...

So far you have some form of neuropathy (nerve damage) and maybe varicose veins (blood vessel damage). Are you currently having any symptoms of an infection: stuffy nose, headaches, fevers, blisters etc? Do you have muscle weakness in the numb hand or foot? Seeing a Neurology doctor is a must...

During the honeymoon, the influx of extra testosterone gives you a kind of high and keeps the nervous system in high gears. That improves all symptoms. It goes away because the brain adjusts neuroreceptors and becomes less responsive to the new levels of testosterone. So the TRT honeymoon is...

Instead of spending months on theories, the easiest thing to do is to stop the Androgel and you will see if your symptoms go away. If they don't, you have something else going on, not related to TRT or testosterone. Then you should definitely go see a general care doctor. Endocrinologists...

Assuming it is not something else, like recent Covid which can fuck up your nervous system (abnormal resting heart rate), I would try lower doses of testosterone. With your low SHBG, your current free T is close to the upper boundary of normal. That is your LOWEST value before the next...

Being cold most of the time suggests suppressed thyroid - this may be related to your low carb diet and intermittent fasting. Start eating normal amount of carbs and see if that improves your symptoms and the T restart. Do you count the calories per day? They may be too low. People on carnivore...

Your friend is sick of something: blood and white blood cells in urine, elevated neutrophils, elevated hemoglobin and hematocrit, elevated bilirubin. He has to go to a doctor. Until this is resolved and blood tests repeated to see what his normal state is, I wouldn't do any TRT. Being sick can...

https://pubmed.ncbi.nlm.nih.gov/17004914/

It depends on your desired improvement and only testing can answer that. Increase of 200 ng/dL in total testosterone is not insignificant.

500iu HCG EOD is a mild dose and probably will recover faster after stopping. The expected increase in total testosterone is about 200 ng/dL while on it.

If injecting HCG leads to the same level circulating testosterone as TRT, it should suppress the LH and FSH (pituitary hormones), just like TRT. The only difference is that with HCG, you are producing the testosterone in the testes instead of injecting it. After you stop HCG, your pituitary...

Virtually all studies on Magnesium are observational. High level of circulating magnesium in the blood indicate a healthy diet, not a magnesium supplementation. The better health is most probably an overall effect of the healthy diet, not of the magnesium alone. That means, if you just...

Unconvincing: the actual data is not presented very few deaths are expected within 5 years in a group of 75 men with testosterone > 1000, so the statistics signal is not strong very few variables are controlled in the regression, so causation is not convincing the higher testosterone is...

Reducing the enormous complexity of aging to lack of one mineral is delusional. If it was that easy as supplying more magnesium to older people, Mother Nature would have done it already for billions years of evolution. Nutritional medicine is currently at the level of pseudo-science. Don't...

Another "study". Basically they prove that feeding the immune system with a fast absorbing energy source (we already knew about sugar, now it is leucine from protein isolates): (1) activates mTOR, (2) leads to acceleration of atherosclerosis in rats genetically engineered to develop...

DHT is measured when you have emerging side effects of TRT (acne, balding, increased prostate PSA test) or lack of the expected sexual boost on TRT. It's not necessary as an initial test and can be skipped, if its expensive or hard to do...

They are finally realizing that anything promoting blood vessel inflammation, in this case excess niacin metabolites, can lead to cardiovascular disease. It's not the cholesterol. https://consultqd.clevelandclinic.org/link-discovered-between-excess-niacin-and-cardiovascular-disease

In my experience, amphetamines (Adderall, Dextroamphetamine, Ephedrine etc) stimulate ejaculation (contract muscles in urethra), not orgasm. You can ejaculate without any orgasm on them. If they contract the urethra muscles too much, ejaculation and peeing may feel burning. On top of that, they...

All tests should be done in the morning, fasted, before your next dose. You can try one time a few hours after you apply the dose to see if it is absorbed. You apply 150mg testosterone but not all of it is absorbed. You should follow the instructions for your particular gel, not what some...

Were you diagnosed by an endocrinologist for all these deficiencies - adrenal, hypothyroid, and hypogonadal? The first few weeks of TRT are the honeymoon period, which eventually goes away and does not reflect how you would feel in the long run. The minimal tests for monitoring are: Total T...

There is a clear theoretical reason for TRT to decrease metabolic and diabetes risk: it shoves the blood sugar into muscles more efficiently. In the "study", there is a clear effect at 6 months and the TRT group always had lower incidence of diabetes but the difference with placebo decreased at...

Not a good idea at all. I bet the STDs will increase even more. It will shift initially the STDs towards even more Hep-C and Genital Herpes. Then, Gonorrhea will develop resistance to Doxycycline, Syphilis may join the fun, and pathogenic gut bacteria for sure will pick up resistance. All...

So the AR inhibit most of the immune system, except B cells. I get latent herpes activation (headaches and cold sores), every time I boost free testosterone (with arimidex, HCG, or Androgel). That made me stop.