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The use of HGH causes glycemic issues to occur in certain individuals, particularly if one were taking it at dosages well above recommended for anti aging, so I was taking it for both reasons mentioned.

To add to your statement, I have a corollary: I am running HGH as well on top of testosterone. I use the Metformin to keep glucose issues associated with HGH in check and to keep my estradiol in range. The deficits associated with Metformin arguably won't apply to someone running HGH given...

I get the same symptoms of fatigue when running Metformin. I find that taking my dose before bed eliminates the problem entirely.

Yes, but only in natural men who are not on TRT, and it does so via the same mechanism as the manner by which it reduces hyperandrogenic symptoms in PCOS patients (hyperinsulinemia causes a spike in FSH which causes androgen producing cells to increase their production). In cases where a man's...

Well, yes. Hyperinsulinemia is a factor in excessive aromatization. The production of insulin stimulates aromatase. Metformin reduces insulin, thereby curbing the activity of aromatase via the aforementioned downstream mechanism. Do note that I am not advocating the use of Metformin as an...

Getting right to the point, study upon study has shown that Metformin appears to be an efficacious aromatase inhibitor. For those of you taking it with TRT, have you noticed any low E2 related symptoms associated with its use? On a side note, this might just solve the myriad of E2 related...