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I understand. Since I stopped losing hair last year when I reduced the cab, it makes sense to suspect it. However, I'm now taking about 1/3 the amount that caused that hair loss, and my hair has been fine in the intervening year. I'm not sure why suddenly it would start up again. Can I...

I'm 54 and have been on anastrozole and cabergoline for over a year. I've been treating high E2 and prolactin. I started with anastrozole and then, after seeing my E2 come down, added the cabergoline. I've normally got a good head of hair, but starting cab immediately caused noticeable hair...

First, I couldn't get anyone to provide feedback on my latest labs. Now my thread with the history of my lab results since last year has gotten trashed by the new forum, which apparently can't handle tables. Very disappointing.

Sorry, I assumed you must be on an AI. Men with high BMI and/or blood glucose can have low prolactin. If these are true for you, then lifestyle changes might help (and they'll help you feel better overall and possibly bring your other hormones in line). The neurotransmitter dopamine...

I agree with this based on my own experience. A bit less AI should move your E2 to the low to mid 20s, which could help your symptoms. I would still focus on the low prolactin as the #1 culprit, though. It's dropped again and these near-zero levels will make you feel crappy.

At the risk of repeating a lot of what's in the other thread, here you go: - I'm not using T. Only an AI and cab. - I've been using the AI a little over a year, the cab a few months less. - I suspect the E2 number because it's dropped by 10 without any change to my AI. Not sure if other...

I cut my dose of cabergoline. Trying to optimize my hormones has been a real balancing act. Frequent blood tests and adjustments are a must, and I haven't been doing blood tests often enough.

I'd appreciate any input on a couple of questions that came up with my latest labwork. Details are here: https://www.excelmale.com/forum/showthread.php?11560-Latest-blood-work-with-a-couple-of-questions&p=115366#post115366 Specifically, are my E2 and prolactin numbers accurate? I have reason...

I'm not on TRT, but I've been having issues related to high E2 and prolactin. I can tell you from experience that if your prolactin goes off the bottom of the scale you'll feel bad. I inadvertently drove my prolactin down below 1.0 using cabergoline. Felt great while it was coming down, but...

Update and question about new lab results Since March, I've been on half the previous dose of cabergoline, now dosing at 0.0625mg E3D. I lowered my dose because my prolactin had gone nearly to zero. I continue to dose anaztrozole at 0.225mg E2D. Latest numbers (most recent first): Range...

I've been taking Cab for about a year now. I started it because my prolactin was several points over the top end of the nominal range. Plus I was interested in the effects on libido. It's definitely a strong drug. I think anyone taking it needs regular prolactin tests. At one point I had been...

I'm thinking I'll go to 50% of the current dose. I dose E3D on the caber to match the half-life of the drug, so I'm thinking I'll skip one dose and then start dosing at 50% which should provide a smooth transition. Looks like caber is soluble in alcohol, so I'll try taking it in solution going...

Update with new blood work 5/17/2017 6/14/2017 7/11/2017 8/4/2017 2/23/2018 Units Range Testosterone, Serum 496 663 ng/dL 264-916 " 504 566 ng/dL 348-1197 Free Testosterone (Direct) 12.1 13.6 11.5 21.7 pg/mL 7.2-24.0 Estradiol 41.5 27.0 17.0 28.1 pg/mL 7.6-42.6 "...

Have had good luck with these guys for anastrozole and other things.

I'm sorry to hear you're having continuing issues. I can't advise you on your dosage, but I can say from experience taking a beta blocker that it works as an anti-palpitation medicine. It's possible that you were prone to palpitations and coming off of the beta blocker is allowing them to...

At that rate you're creating a solution of 0.2mg/mL, which is well below the solubility limit of anastrozole. I've read posts (elsewhere) from people who've tried creating a 1mg/mL solution and found crystals in the bottom of the vial due to the excess anastrozole. This is what I'm trying to...

Sorry. I overstated. Anastrozole is soluble in water up to 0.5mg/mL, thus you cannot make a standard 1mg/mL solution out of it.

Anastrozole is soluble in alcohol, not in water. The solution you get with vodka will have solids that don't dissolve, but those are fillers from the pill. Just make sure to mix before dosing. With dosages as low as you're going to need, it might be more accurate if you create a more dilute...

On the subject of vasectomy - I had one shortly after our second kid was born. It was easy and sooo convenient because my wife couldn't take oral contraceptives and this solved our problem. Some years later I found a lump on my left testicle and it was tender. Got an ultrasound and the...

This is an eye opener. I took Propecia starting in my late 30s for about 10 years and never thought of it as doing anything negative to me. Over that time I gained (more) weight and started having ED issues, but I figured the two were related to poor lifestyle choices. Never had a libido...

^ This is what I've been wondering. You're the first to directly state it. Having metabolic syndrome / diabetes, organ function becomes compromised. I've had fatty liver for 20 years or so - was diagnosed before they understood what it was a precursor for - so my AST and ALT tend to be...

Yes, I'm managing my own hormone therapy at this point. It's not ideal, but after being told by two doctors that there was nothing wrong with my hormones, I'm wary of trying to find an endo or physician who will do the kind of targeted treatment I'm attempting. I don't just want to be thrown...

FWIW I'm 53 and I've been on daily generic Cialis for over a year and swear by it. I can get hard anytime so I never have to plan ahead. As a side benefit, it also seems to have dropped my BP.

Thanks for the clear definitive answer! That's what I wanted to understand. Okay, here are my recent blood tests. TT around 500 ng/dL against a range of (348-1197) or (264-916). Slight increase in July shortly after starting anastrozole and a...

I have slightly below-average TT and my LH and FSH are near top-of-range. Some have suggested this is primary hypogonadism. Since I'm starting with high LH/FSH, would it be possible to take a small enough dose of testosterone to have some benefit, while bringing down but NOT killing LH/FSH...

Yes, a dry read to be sure, but information that looks to be helpful. Thanks for the links. Really what I'm hypothesizing isn't so much a complete blocking of AR action as it is a reduction in it so as to make it "look" to the HPT axis as if your testosterone levels are flat, despite the fact...

And this is the trick, isn't it? It would have to be a selective AR blocker targeting only androgens in the hypothalamus (or perhaps the pituitary as well). Too bad if it doesn't exist yet. Sounds like it would be the holy grail of TRT.

Thanks, but that's not really what I was asking. I want to know if there's a better alternative to HCG that stops the hypothalamus from detecting the testosterone supplementation of TRT.

I don't think I ever did adjust to the lower dopamine levels, because after seeing my labs from 5/17/17 I went back on bupropion SR, albeit at a smaller dosage (was 150mg/day, then zero, then 75 mg/day). By 6/14/17 my prolactin had lowered nearly 10%. After 7/2/17 when I started the AI it's...

I know you're not focusing on dopamine anymore, but I did want to post for anyone who finds this thread later and share my thoughts about how dopamine plays in all this. I had high E2 (40+ pg/mL) for about two years. I couldn't convince either my PCP or an endocrinologist that it was an issue...

I’ve been doing a little reading about the HPTA, as I’ve been considering TRT and want to understand what it really does. This led me to a (perhaps stupid) question. It seems that standard practice is to use HCG in addition to supplemental testosterone if one wants to preserve his natural...