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Here is what consistently comes out with one full rotation.

Thanks. The last few lines address my situation. "Normal eGFR are those above 60 ml/min. If your GFR is under 60 ml/min, please consult your doctor. "Note: Creatinine clearance reductions of under 60 ml/min are rare in men using testosterone replacement therapy, but always keep an eye on this...

I just got back some labs and got reminded that exogenous testosterone beats up kidneys. I posted about it here. My TSH went from <0.01 UIU/ML, 0.400-4.1000 on 2/12/2021 to >100.000 UIU/ML almost exactly a year later on 2/15/2021. 02/12/2021 TSH REFLEX TO FREE T4 <0.010 UIU/ML, 0.400-4.100...

As I feared would happen, my creatinine and eGFR levels are getting worse while on even low doses of testosterone. 02/12/2021 pre-TRT Creatinine 1.10 ML/MIN/1.73, 0.80-1.40 eGFR African American 93 ML/MIN/1.73, >60 eGFR non-African Amer 81 ML/MIN/1.73, >60 11/06/2021 pre-TRT Creatinine 1.36...

I found this anecdotal gem about adding clomid to TRT in a thread about why clomid doesn't work while on TRT. https://www.excelmale.com/forum/threads/clomid-testosterone-why-they-dont-work-together-by-mike-gaiso.9421/page-2#post-64811 "I did 50 mg for 2 days to jump start, and have been doing...

I see my endo next week. My numbers were good last time, TSH 1.07 UIU/ML, 0.400-4.100, Free T3 2.8 PG/ML, 2.2-4.2, Free T4 1.32 NG/DL, 0.80-1.90 but I think I've developed a bit of goiter, even though I'm up to 60 mg/day of methimazole, which is a lot. I have nodules and was going to have...

Update: I don't know if the existential, geopolitical stress or what, but my libido has almost completely dried up again. Looks like that surge was just a random one. Let's hope it comes back with a few weeks at the higher, less frequent dose and enclomiphene. @Cataceous, Defy has me doing labs...

It's been a few years on methimazole, and maybe a year on the other two. I sleep well, but I get up after about four hours, every night, no matter what time I go initially fall asleep. But I'm always able to get back to sleep for a few more hours.

I do get nighttime erections, but was having zero urge to masturbate for several weeks. Things just started to turn around last night after a couple of spaced-apart injections at higher doses. I'm sure my dopamine and norepinephrine systems are a bit jacked from a few misspent years of living...

Anecdotally: I tried starting low and slow with 10mg t-cyp/day. Libido and penile sensitivity dried up after five weeks. I recently decided to do 60 mg/3.5 days and within two injections, my libido and sensitivity are surging. I think I mainly needed a higher dose, but I suspect the peaks and...

Yep, this may just be honeymooning. Everything I read has me anticipating this libido will wear off in a few weeks. But with the bigger dose, everything is suddenly working: penile sensitivity, erection strength, morning erections, and actual libido. I wish it could be as simple as taking a week...

And my SHBG went down to 21.5 nmol/L from 31.5 nmol/L while testosterone is essentially unchanged. Since hCG supply is being disrupted, Defy agreed to switching me over to enclomiphene as part of a clinical study. So I'll be doing test cypionate at 60 mg/3.5 days along with enclomiphene at 25...

I was one of those people running 250mg+ of test cyp/week and messing with stuff like Proviron and cabergoline. There was also some tren. Looking back, I realize my libido was sky-high back then; I just didn't have any libido for my actual partner, and that's what I was trying to fix. Libido is...

I just got blood work back... TESTOSTERONE, TOTAL, MALES (ADULT), IA 294 250-827 ng/dL EN ALBUMIN 4.4 3.6-5.1 g/dL EN SEX HORMONE BINDING GLOBULIN 21 10-50 nmol/L EN TESTOSTERONE, FREE EN TESTOSTERONE, FREE 52.9 46.0-224.0 pg/mL TESTOSTERONE,BIOAVAILABLE 106.4 L 110.0-575.0 ng/dL The...

I am trying the Empower version, and I'm feeling absolutely nothing so far. According to the pharmacy, one full rotation is 11 mg of testosterone, and I take that dose twice a day, right nostril in the a.m. and left nostril in the p.m.. I've tried to explain to Defy why I'm trying nasal gel...

Thanks. I'm still not sure about nasal gel monotherapy though. In order to pursue that, I'd have to ignore Defy again for several months, and I'm not sure if I should keep doing that. This absence of feeling in my nether regions has me both panicky and depressed. It feels like I've lost one of...

Making sure HPTA function is restored: you mean another few weeks with the nasal gel alone?

100 mg/ week of T cypionate seemed arbitrary to me, so I figured I'd use physiological production as a guide to come up with something more appropriate. But we've heard it said that a mg of exogenous test is not the same as a mg of endogenous test. Maybe I just need a higher dose? I'm...

Not sure yet.

Yes, should last 30 days on 2x/day.

My point was that test cypionate injections made things worse, so I don't know about continuing. So it's impossible to fix libido. There's no way to isolate and fix all those factors. I was diagnosed hypogonadal; I am pre hypertensive, but doctors won't medicate me for it; I have Graves'...

Instead of taking Defy's dosing advice, I tried going "low and slow" for six weeks, but my libido and sensitivity completely dried up after a couple of weeks. Defy had recommended 100 mg T cypionate/week, divided into three doses, but I went with 10 mg/daily. They have also recently added hCG...

$65 for the 3-mL pen with 5 mg/0.05 mL concentration; $79 for the 3-mL pen with 10 mg/0.05 mL concentration. The higher concentration is obviously the far better deal, so I'm dosing that 10 mg/0.05 mL twice per day, which should yield 30 days of use.

Nothing from initial dosing. I even popped half of a Cialis.

Thanks! I was able to get on the phone with an Empower pharmacist. As I was waiting on hold, I did a couple more full rotations (8 clicks) and the gel eventually oozed out! It took a total of three full rotations to get this to happen, so I have no idea what my actual fist dosing really is. I'm...

I received my first nasal gel pen in the mail from Defy today, but it came with no instructions on how to actually use the pen. The only moving part is the rotating clicker at the bottom. I rotated it fully (several clicks), but nothing came out the dispenser. There is no pump or any other...

Because I mentioned testicle size as a concern, and I was told enclomiphene was for fertility, not testicular size. I also had to choose between nasal gel and scrotal cream. It looks like they think I'm using the gel as an occasional boost as opposed to a solo therapy. I also mentioned to her...

Sorry, I misread. I will let you know as soon as I feel anything working. Any advice on application and avoiding discomfort or wastage?

Thanks! I see you are on nasal gel x 2/day + 100IU hCG daily. As noted, I got some hCG, but I'd been hoping for enclomiphene. I guess you are finding benefit to adding hCG. I wasn't going to use my hCG with the gel, so I'm really curious.

I just ordered a few of the pens, but Defy wouldn't release any enclomiphene; prescribed hCG instead. Maybe next time. I'm taking a break from cypionate injections after five weeks of injecting. Hoping I'll be recovered HPTA-wise a bit by the time the gel gets here. Will try the gel by itself...

This is good to know, thank you. How are you feeling on the enclomiphene only? Libido, anxiety, any eye floaters? I find this fascinating as my sex drive has completely crashed since I started a low-dose injection regimen of 10 mg t cypionate/day. I had been toying with the idea of stopping for...