Search results

During my most recent consult with Dr. Calkins, he recommended starting BPC-157 (250mcg ED SQ) and CJC-1295/Ipamorelin (350mcg ED SQ). The former because I just had surgery to reattach my left distal bicep tendon (8/11/2020), and the latter because my IGF-1 has been trending down over the last...

I am a patient of Defy and currently my status is on hold as I am working with a local endocrinologist to get to the bottom of a suspected thyroid issue. Right now I am having difficulty getting the endo to prescribe thyroid antibody tests (TRAb, TPOAb, and TgAb). I also cannot request my own...

I'd cut the DHEA.

I have no idea. I could be completely wrong, so here is my very simple thought process; low SHBG results in higher clearance rate of testosterone, which limits the available pool from which E2 can aromatize. And any E2 that is aromatized would have a similarly high clearance rate.

Yes I get my script from a compounding pharmacy. I'm a patient with Defy; not sure why Dr. Calkins went with 15 mg instead of 12.5. Maybe because of my weight (210#)? My E2 has increased as my testosterone has gone up, but the number seems reasonable and I haven't noticed any E2 related side...

I'd tell her that you only agree to try if she starts you out at a very low dose (something like 12.5 mg ED, or 25 mg EOD), and you reserve the right to stop at any time if you don't feel any better (or feel worse). For what it's worth, in my case I wanted to try the easy road of taking a pill...

I think that theory only holds if a person had zero estrogen to begin with.

By the way, I've been on 15 mg of Clomid every day for around 11 months. My total testosterone went from 400 to 700 ng/dl, and improvement in strength and sexual function was very pronounced.

For each estrogen receptor an antagonist occupies, that is one less receptor for an estrogen to activate. The net effect is to make your estrogen level appear lower than it actually is, thereby stimulating more LH.

Your understanding of Clomid is not correct; Clomiphene can act as both an estrogen agonist, and an antagonist. source "Clomiphene citrate works as an estrogen antagonist at the level of the pituitary gland and thus stimulates the release of LH and FSH, which in turn drives both the...

I take 15mg ED, and my total is just over 700 ng/dl. But always remember, your mileage may vary.

Not necessarily. For example, the aldosterone and cortisol hormone pathways share many enzymes (e.g., 21-hydroxylase). A deficiency in any of the shared enzymes would affect both pathways. The only way to know for sure is to test both, as well as the relevant hormone precursors.

Have you had blood drawn for the sensitive (LC/MS-MS) Estradiol (E2) test? Your symptoms line up with low E2. Also, anecdotally most of the vision problems on Clomid correlate with starting at too high of a dose (i.e., 50mg).

See this thread for background. Here are my 4-tube salivary cortisol results: Any help interpreting these results would be greatly appreciated.

So here are my results: 6AM: 0.295 11AM: 0.115 5PM: 0.045 11 PM: 0.016 looks like a normal shape, but the values seem low. Is that a correct interpretation? What, if anything, should I follow-up on?

Thank you Doctor! I just sent you a direct message.

check your inbox. If you don't see a msg, let me know.

Expect a DRE for sure. Assuming the DRE doesn't rule anything out, I'd lobby for a prostate MRI before ever considering a biopsy. I did the biopsy before the MRI (stupid, I know). Biopsy was negative (18 cores, ouch), and the MRI showed a very large prostate (almost 50cc). Larger prostates...

You need to eat, like a lot. At 74" you could carry 210 pounds and still be fit if you lift (and eat).

Here is all I have for thyroid: October 2016 TSH: 0.651 (0.450 - 4.500) Free T4: 1.59 (0.82 - 1.77) Free T3: 3.2 (2.0 - 4.4) November 2016 TSH: 0.78 (0.47 - 4.68) Free T4: 1.6 (0.8 - 2.2) May 2017 TSH: 0.95 (0.47 - 4.68) November 2017 TSH: 0.63 (0.47 - 4.68) Free T4: 1.2 (0.8 - 2.2)...

Symptoms: - difficultly getting going each morning - crash between the hours of 1-4PM every day - perk up in the evenings Suspect some sort of adrenal dysfunction. DHEA-S: 424.5 ug/dL (102.6 - 416.3) Progesterone: 2.62 ng/mL (<1.40) 40 y.o. male, 6'1", 200#, 15 mg Clomid ED. 5000IU D-3...

I'm on 15mg ED and no AI, and libido is very good. I'd start with titrating your AI down first.

I have elevated PSA (~5) and a large prostate (~50cc whereas normal is 15-30cc). A larger prostate will make more PSA, so PSA density can be relevant: for example mine is 0.1 PSA/cc whereas "normal" could be as high as 0.267 (4 PSA/15cc). Regardless, I'm fairly confident I have an infection in...

Do you have difficulty awakening from sleep in the morning, often hitting the snooze button multiple times? Yes Do you need coffee to get going in the morning? No Have you recently gained weight, especially around the middle? No Do you feel like you get every cold and flu bug that is going...

So either healthy adrenals or fatigued adrenals? The symptoms are the same in either case? If fatigued, what else can I test to try to confirm?

So no problems, but the numbers seem weird.

I seem to have higher than normal DHEA and Progesterone. What are some things to look into regarding possible cause(s)? Most recent results: https://imgur.com/a/2A6ac Protocol: 15mg Clomid ED (high DHEA and Progesterone predates Clomid usage) 40 y.o., good health

Her free and total test were indeed high: 5.3 pg/ml (0.0 - 4.2 pg/ml) 49 ng/dl (8 - 48 ng/dl)

Hi - My wife and I are patients with Defy. She had been taking 25mg DHEA ED with good results: increased mental clarity, energy, and mood. Unfortunately it was causing her to lose her hair at an alarming rate. After her most recent consult, it was decided to drop down to 12.5mg ED. However...

Ask for a sensitive E2 test. Possible your E2 dropped below your body's sweet spot.

I do seem to have more motivation (or less hesitation) to work-out, and more energy/stamina when working out. Other than that I haven't noticed a dramatic increase in energy but that could be due to my crappy sleep.