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I notice a difference about 10-12 hours after injection which I attribute partially to the hcg and partly to an increase in estrogen

Cmon, man. Pee on it, and it still turns positive??

Good question. I don’t know how the strength of hcg is regulated. It’s not the same as testosterone. One compounding pharmacy of 6k ius could be slightly different than another

My body is super sensitive to HCG. I notice a slight difference in the strength about 5 weeks after reconstituting. There is a difference and Empower will tell you it starts to degrade after 30 days. Most people probably would never notice

Many legit clinics prescribe 200 mg a week. It all depends where you should be and where you do best at

I think hcg could play a small part in penis sensitivity reaching all those LH receptors. But, for me and I think most people, your estradiol levels control your sensitivity. It’s normally low estrogen that would lower your penis sentivity, but high estradiol can do it as well. Of course if your...

I know that Defy has done some small studies with their patients. This would be a perfect study and should be fairly easy with a larger number of patients than what they’ve used

I’m so glad to see others have had the same results. I had both the sensitive and regular run from same time blood draw twice. On one it was a point or 2 difference and on the other it was only 3-5 points difference. It makes me wonder if it’s really worth it and why so much hype over the...

One of the things that reamins a mystery is why I could take 150ius daily with no problem 2-3 years ago, but now I can't even take 120 EOD. It doesn't make sense to me

Well, I cannot just drop it. I wish it were that easy. I am at a Test level in the high 700s but my estradiol level is at 15 without it keeping my test and anatsrozole the same, and I have no sex drive and no penile sensitivity with my estradiol that low. On just 110 ius EOD, my test level goes...

I am taking much less HCG than I did just 2 years ago with more of an effect and more side effects. When I originally came to defy, I was dialed in eventually to .28 mg of test EOD and .25mg anastrozole 3X a week. I was told by Crisler originally to take 100ius of HCG with that. After a follow...

I've had some challenges over the past 9 months on getting dialed back in again which have been mainly due to HCG. I am ready to either cut it down to a minimal part of my protocol or go back to using it daily as opposed to keeping it EOD. When I first came to Defy, Dr Crisler suggested 100 ius...

If your doc really suggested that, I would seriously consider finding a new doc

Did I read that corrrectly? A 2500iu dose? That’s what a doc would give you to try and restart your hpta, if you were getting off testosterone. You think you feel bad now. You would feel awful if you injected 2500ius at once

That’s not how anastrozole works. If you got your blood drawn before your next day injection and then take it right after you inject, it should just keep the testosterone you injected from converting to estradiol. If you take a lab the next day after you inject, your estradiol will be higher or...

Hcg can make a big difference. It did for me. It could be that you're gettung older. You could always get off trt and see how you feel. I thought about doing it recently, since trying to get dialed back in has been a Royal PIA. But, i did it 3-4 years ago and just felt ok and wanted to get back...

As far as subq vs im, everyone has their preference. There's absolutely no differentiator biologically, unless you inject subq into fat which in theory makes for a slower absorption and less spikes. The whole theory of more frequent injections and subq vs im is to make it simulate closer to...

My experience has been a 4 at first and now it's a 1. I had been on 100ius-150is daily gradually going up while on TRT and didn't seem to get much subjective benefit or a feeling of well being like I was told I should feel, but I did notice that sex was better and penile sensitivity was better...

My SHBG was just run on 4/6, and I’m at 25.9 so well within normal levels. I’ve never run an estradiol free. I’ll ask Jill about it. What would that possible tell me?

My protocol that I had been on for a year was changed by a new doc I had not met with before. It had taken a while when I got to Defy and working with Jill to get me dialed in, but I had finally gotten there and was feeling great...libido was very good, felt good and had good quality erections...

Being inconsistent, especially with anastrzole, is a problem in itself. I agree with Vince and Vince and reasons why to only change one thing at a time. But, if you're not consistent with your anastrozole, you're definitely going to have problems. I print out a calendar and right the dosage down...

So, next week. I would normally take .25 anastrozole sunday, Tuesday and Thursday. What I am proposing more like suggesting is that I take it an additional 3x on Monday, Wednesday, and Friday just for next week to get it down from the 40s which is where it is right now to a lower amount. And...

The really frustrating part is that I did state this. The new doc thought it would be better, and I reluctantly agreed to try. Afterward I realized that I didn't want to try, because I felt great and had already been through a lot to get dialed in. I actually called back and told the staff that...

So, it can take up to 12 weeks to fully feels as good as I did before getting back on my old protocol that was working? Jill was hesitant about me adding in hcg so quickly after my estradiol being high, but I didn't think it would take this long. Like I said I was on 150ius daily. They increased...

I’ve been on Trt for several years, and I’ve had issues with estradiol. I was finally dialed in after going to Defy for a year. I was on .28ml of test eod, .25mg anastrozole, and 150ius of HCG daily. I felt great, my libido was very good, and erection quality was outstanding. My tt level was...

Your estradiol may be too high. It’s within normal range, but if you are estradiol sensistive like I am, your morning wood and best sexual performance may be at an estradiol level of 20-25 like me. If I’m close to or at 30, my sex drive, morning wood and everything goes down

I should have been clearer when I said no direction on medication. They give me the basic take 2 of these type of direction. I'm referring to getting dialed in on my estradiol with medication

In almost a year since I've been a patient of defy, I've only had one interaction with. Dr. which was Dr. Crisler. I gave him all my previous labs which was about 15 over 2-3 years. He was a bit confused with all of the information and pinpointing where to start. I didn't put the blame on him...

I joined defy because of all the great reviews I came across on here. I've been very displeased by their staff so far. I'd be happy to go into more detail, but I'll give one of many examples. My biggest issue like many others on Trt was estradiol management. When my estradiol is in the right...

Does SHBG change? I thought it was a pretty static number that you're stuck with...not something you van change. Have to admit I don know much about Shbg

Interesting to see this post! I've had 2 blood draws several months apart and had the sensitive e2 test run from the same blood draw and both times the difference was statistically insignificant, within a couple of points. I've seen no difference between the tests personally. I'll post the lab...