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Which "part" of the HPTA is the hardest to "turn on" during PCT?

I am getting off testosterone after two years (if you want back story, you can read my previous posts, and I'm unable to perform any conventional PCT as I cannot tolerate SERMs. I have, however, been entertaining the idea of using GnRH or hCG as a way to "prime" the body before coming off TRT...
- JustPanicNoDisco
- Thread
- Oct 2, 2022
- cold turkey gnrh hcg pct
- Replies: 4
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
J
SERM "PCT" Alternatives

I'm strongly considering getting off TRT after being on 1.5 years and worsening my health tremendously. Since I'm suffering from an abundance of low E2 symptoms which I would probably exacerbate majorly if I were to use SERMs. Are there any other good alternatives? Anything that antagonizes...
- JustPanicNoDisco
- Thread
- Aug 19, 2022
- gonadorelin lowe2 pct triptorelin
- Replies: 23
- Forum: Testosterone Basics & Questions
J
Very high FT on 70mg/wk?

I just got my blood results back. I have been lowering my testosterone dose significantly over time, as I was experiencing many side effects on higher doses, which I thought may have been in part due to the high T:E2 ratio (seemed it didn't rise proportionally). I'm running 70mg of test cyp per...
- JustPanicNoDisco
- Thread
- Mar 22, 2022
- free test high low e2 skewed ratio
- Replies: 57
- Forum: Testosterone Basics & Questions
J
Help Smoothing this Transition from Blend to Test E? (Math)

I'm currently running a daily blend consisting of 5.625mg testosterone enanthate and 4.5 mg (i.e., a 5:4 ratio of test E to test P). I am hoping to transition off the test propionate back to solely enanthate, mostly for quality control reasons (I can only buy the propionate online, and given...
- JustPanicNoDisco
- Thread
- Jan 27, 2022
- graph transition
- Replies: 1
- Forum: Testosterone Side Effect Management
J
Paradoxical Increase in Adrenal Activity from Exogenous Test?

All the literature I've read suggests that exogenous testosterone tends to have a suppressive effect on adrenal (and potentially thyroid) activity. It makes sense -- if your body has enough hormones, you won't be generating as much pregnenolone -> other hormones (including cortisol downstream)...
- JustPanicNoDisco
- Thread
- Oct 1, 2021
- acth adrenaline cortisol
- Replies: 3
- Forum: Testosterone Side Effect Management
J
Has anyone felt better with more fluctuations (perhaps mimicking diurnal patterns)?

Most TRT regimens seem to use test C and test E and keep levels relatively stable. Most using these don't experience the natural diurnal fluctuations that would occur naturally (rising in morning, lowering in afternoon, and rising again at night / early am). Has anyone felt better after adding...
- JustPanicNoDisco
- Thread
- Jul 1, 2021
- diurnal test prop testosterone fluctuations
- Replies: 10
- Forum: Testosterone Basics & Questions
J
Debate - Androgens: Estrogen ratio vs Overall Hormone Levels.

I searched here, but I couldn't find any in-depth discussions about this specific issue. If anyone has any literature they would mind sharing on this topic, I would be extremely interested to read it. A couple questions: 1) Will you suffer from having too high of hormones, generally...
- JustPanicNoDisco
- Thread
- Jun 13, 2021
- advice oxandrolone proviron sore joints t:e2 ratio total hormone levels
- Replies: 9
- Forum: Testosterone Basics & Questions
J
HELP - Heat Rashes, ED, and Cracking Joints - A journey Riddle with Side Effects

To preface this, I am a post-drug patient with lasting sexual side effects (yes, PFS, PSSD, and PAS exist and I will not argue this). I have had enduring sexual dysfunction (dead libido, loss of morning wood, weak erections, etc.) for about 5 years since discontinuing psychiatric drugs. Most...
- JustPanicNoDisco
- Thread
- Apr 7, 2021
- antidepressants ed joint ache libido pssd rashes
- Replies: 9
- Forum: Testosterone Side Effect Management
J
Adipsia/Complete Loss of Thirst + Skin Elasticity Changes

To preface this, I've been on TRT at 200mg/wk, daily IM, for 8 weeks. I recently got labs and sodium, potassium, chloride and all blood markers came back within normal range. Before starting TRT, my thirst levels were normal and I didn’t have these… skin elasticity issues. I don't know exactly...
- JustPanicNoDisco
- Thread
- Feb 23, 2021
- adipsia collagen synthesis skin elasticity water retention
- Replies: 3
- Forum: Testosterone Side Effect Management

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038