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I've just discovered that SHBG levels will determine what injection frequency is best for the individual. My last two SHBG tests were 36 and 42, range 18 - 57 nmol/L Are these considered high, optimal, or low?

I'm wondering if anyone here on the forum started off feeling bad or so-so on TRT and then with adjustments figured out a protocol that gave them the big 4: libido, erection quality, energy, stable mood. I've seen this referenced as being "dialed in". If you are one of these dialed in guys...

Are there any scientific/medical explanations as to how and why high estrogen will cause weak erections or "up and down" erections and/or a poor libido? Also of note, why can PDE5 medications ( Cialis, Viagra ) mask or override high e2 and allow for a decent erection? Does high e2 do something...