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Fatigue, anger, swollen ankles, etc.

I'm currently dealing with a few things that may or may not be TRT related. I scoured these forums to see if I could find help with no conclusive answers. Background: 38, 5'11", 205lbs TRT since Feb 2018, currently 138mg/week (3x) + 500IU HCG (2x) + .125mg Anastrozole 2-3x as needed DHEA 25mg...
- Reason
- Thread
- Apr 22, 2019
- anger difficulty breathing estradiol fatigue side effects swollen ankles
- Replies: 14
- Forum: Testosterone Side Effect Management
Help with Follow-Up Labs Cost and Alternatives

I have my first follow-up consult with Defy and the labs they've requested are double the initial cost projection of $250, to about $500 so I'm looking for help figuring out my options. I've Kaiser in NorCal and they won't cover labs from outside network physicians. My primary didn't want to...
- Reason
- Thread
- May 23, 2018
- Replies: 7
- Forum: Blood Test Discussion
Recent labs: HIGH Estradiol. Causing sleep issues?

These are labs from mid Week 7: Total T: 957 ng/dL (264-916 range) Free T: 25.6 pg/mL (8.7-25.1) E2 Sensitive: 60.6 pg/mL (8.0-35.0) SHBG: 27.1 nmol/L (16.5-55.9) This is really high, right? I've also ordered a complete follow-up panel but because of Defy's scheduling quirks, I had to wait...
- Reason
- Thread
- Apr 16, 2018
- Replies: 23
- Forum: Testosterone Side Effect Management
Started my journey. Thank you.

Started my TRT journey yesterday. After spending most of my life in a rut, hitting a wall every time I tried to get better, I decided to take the plunge. I'm 37 and never thought I'd have to be on hormone replacement therapy at this young age. But here I am and I'm very excited for the future...
- Reason
- Thread
- Feb 22, 2018
- Replies: 27
- Forum: Testosterone Basics & Questions
Guidance with Initial Labs (very low Free-T)

Help Reading Initial Labs? Hey all, New here, first post! I just got my initial labs en route to a Defy consultation (2-3 weeks out). I'm somewhat new to this so I would really appreciate some guidance reading the results. Background: 37 / 5'11" / 190lbs / ~18-20% body fat Gyno as a...
- Reason
- Thread
- Jan 26, 2018
- Replies: 11
- Forum: Blood Test Discussion

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038