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Research consistently shows that a low testosterone threshold requirement exists for libido and sexual function. I believe they found the TT level for this to be in the 400s. Thus testosterone has some veto power over libido, but it alone is not sufficient to guarantee it, regardless of the...

Phil and Vince: I am moving these posts back to a thread we already overran... https://www.excelmale.com/threads/post-trt-libido-is-dead.33824/post-309860

I see a statement that 100 mg per week is better than 200 mg/2 weeks, not that it's some ideal starting protocol. On the contrary, they say, "In general, smaller dosages at more frequent intervals are preferred over high, less frequent administrations to limit the duration of time spent outside...

That's a pointless remark if you don't have specific examples that have bearing on this thread. Of course peer review is supposed to lessen the odds of this happening, and it certainly makes studies more reliable overall than anecdotal evidence. This doesn't change the fact that it is wrong...

This statement is completely false and unsupported by any evidence. It's also opposed by formal recommendations for starting TRT with midrange testosterone levels, which are based on studies involving thousands of men.

You had a nice honeymoon period on the initial weekly 80 mg TC dose and then crashed about the time that HPTA suppression took full hold. You've proved that more testosterone is not the answer, and you may be making things worse with the excess, crashing SHBG, feeling the need to manipulate...

We have debated this subject a lot. You have been dosed at a level that is likely on the order of double what your healthy natural production would be. It's no surprise that your numbers are off the charts. A lack of acute effects does not imply long-term safety in such levels. Hematocrit may...

Here are the things that caught my attention during a first pass through the article: SHBG-bound testosterone doesn't enter cells, doesn't activate androgen receptors, and doesn't produce the physiological effects you associate with having healthy testosterone levels. This issue is minor and...

You have offered very little to support this claim. You continue to point to the fact that taking 50 mg TC once per week yields poor results. This says nothing about how achieving physiological levels via divided doses of 50-75 mg per week compares to the above-physiological doses that you...

"Jumping to an absurd absolute." You mean like saying "And it is CLEARLY superior to 50 mg/week… no matter how you split the dosing." There is a significant cohort, myself included, that does much better on 50 mg TC per week split appropriately than at the excessive 100+ mg/week level you...

The cognitive dissonance lies with the one who acts like he can't distinguish between different dosing patterns for the same amount of testosterone in a given time period. By this way of thinking you can take your 5,200 mg of testosterone cypionate on January 1st and say you're done for the...

I wasn't even thinking about that aspect—the a priori artificial HPTA suppression—but that makes the comparison even worse. Nonetheless, a sustained protocol of 50 mg TC/week in one injection is still going to be highly suppressive, leading to hypogonadism later in each injection cycle. This is...

You rely on a straw man argument by making the comparison to a protocol that induces hypogonadism; after all this verbiage you still have not cited one study that directly compares our positions. You also don't respond to the assertion that your approach to TRT is out of line with science-based...

As if AI vomitus could save the day for you. The half-life of testosterone cypionate when injected intramuscularly is approximately eight days. Garbage-in, garbage out... That figure stems from old research that did not account for the interference of natural production.† Still waiting for...

Not one study saying that it is appropriate to start TRT with supraphysiological levels of testosterone. Many saying to start at mid-physiological levels. End of story.

These numbers are not estimates: they are a complete joke, and have no relationship to the real world,—except perhaps that 250 ng/dL as a trough for 50 mg TC/week. The peak for weekly TC injection is going to be two to three times the trough level. This falls out from the half-life alone and...

It's presumed that the lack of excipients gives Xyosted its relatively long have-life of 10 days. This is around double that of typical enanthate and cypionate formulations, and makes once-weekly injections feasible. I also like to call attention to the fact that the starting dose is 75 mg/week...

The big problem is that once-weekly dosing of 50 mg TC leaves most men hypogonadal later in each injection cycle—so the pattern is not remotely physiological. Obviously this causes problems. As a starting dose 50 mg must be divided, probably into at least EOD injections, even though some might...

Pair that with your low SHBG back then and you still had upper-range free testosterone, presumably at a trough. Peaks would then be over-range on the E3.5D protocol.

These parameters most likely can be improved sufficiently with the restoration of normal youthful levels. There's no evidence that going above what's physiological improves longevity. IGF-1 is a double-edged sword. It's useful, but also pro-aging. Maximum longevity is linked to levels that are...

I never had anxiety in the context of TRT. If anything, TRT lowers my anxiety, though paradoxically it also impairs sleep at higher levels. Not long ago I did report that in the context of short trials with clascoterone I developed anxiety, leading me to stop using it. The apparent resolution of...

I "handled" higher levels for some years, but came to realize the harm they caused was outweighing the good. I loved the boost in athleticism, but the persistent headaches along with impaired libido and sexual function pushed me to keep experimenting. I would guess I had normal testosterone...

I have always said that if you prioritize musculature over general health then higher doses are the way to go. That's not supporting your case. The average guy would rather just feel good and not risk the side effects. At a minimum, he should experience healthy normal levels so he has a point of...

Most charitably, you are continuing to troll. Otherwise there's a severe reading comprehension issue. In this very thread I described how higher levels of testosterone are actually rather numbing for me. On the health front, I have a BMI of about 22, body fat of ~12%, stellar lipids, I exercise...

So are you now at least acknowledging that it is prudent to start by targeting healthy normal levels? Precisely zero. The only significant benefit of higher levels is improved musculature / body composition. For most men this is easily outweighed by the increased risk to overall health...

If I knew I wouldn't have asked you to provide the details—what are they? But to get to the heart of the matter: Are you agreeing with Phil that by default, hypogonadal men starting TRT should not have the opportunity to experience testosterone levels close to their healthy natural levels? They...

Your usual retreat to ad hominem statements merely highlights your inability to defend your position. Your bad advice has almost certainly harmed some men. Neither you nor Mr. Goodman can articulate why starting TRT at supraphysiological doses is a good idea. You'd be hard pressed to name other...

See below It is, as it results in non-physiological levels for a vast majority of men. Since you're so fond of anecdotes, take a spin through the Excel Male forums and look for posts describing symptoms that are clearly linked to excessive doing, such as elevated hematocrit. This will be...

Once again you're projecting. You foist high doses on anyone looking for help because you think they work for you, even though you don't acknowledge having tried anything else. You're a perfect example of the bias inherent in the anecdotes that Phil Goodman relies on. Meanwhile, I would expect...

Two can play that game, but I can get favorable results with a neutral question: Question: Statistically speaking, based on all information available to you, which approach is more likely to maximize quality of life for hypogonadal men? Based on a comprehensive review of available medical...

I reviewed every one and It appeared that you hadn't read them; many have no bearing on the discussion, and at least one provides direct evidence in favor of physiological dosing. None support the premise that supraphysiological dosing is preferable to physiological dosing for treating...