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Something is really off here, and I think it relates to the slashes: cyp/enanthate, shallow IM/subQ. With labs this wrong, you need to isolate variables, and eliminate the slashes. I feel like you are either injecting a bunk formula or subQ'ing into some thick "black hole" fat like the love...

Daily injections, switch to once daily topical, or switch to oral. Or better yet, attack the root cause, because no one who reaches 53% on 70 mg a week is healthy.

I would vote cypionate, and there is no special transition method required. Just start it at the dose you plan to use. You will reach 80+ % of the final steady state levels very quickly.

In my recent tests, I've had lower T/E2 ratios with prop (32:1 at peak, 38:1 trough) than with cyp (40:1), which seems not to agree with the theory. Maybe the theory is more applicable at extreme short half-lives, like with nasal T, test suspension, etc.

A TSH of 2.8 without the rest of the thyroid labs doesn't support supplementing thyroid hormone. That would be like starting TRT because your LH was on the high side of normal. Similarly to hypogonadism, many symptoms of hypothyroidism are non-specific and shared by many other causes. In...

Was your reverse T3 similarly high before you started supplementing NDT? I don't see your baseline thyroid labs here. Are we sure rT3 isn't high as a result of the intervention?

Yes, that's the joke I'm making here.

That's because placebo doesn't release as much norepinephrine! Lol

I used to be huge on the chronic infection explanation for CFS, but neither I nor anyone I know had any success with it. There are some specialized tests you can take for Lyme disease, very popular in the chronic Lyme community, which always turn up positive. I took one of these and used it as...

Yes, at risk, but we have current (like less than a month old) janoshik results from Jera showing it's good.

Many of us do notice a difference in effectiveness, which has not been well documented in the few studies that exist on the topic. Maybe 30-40% of men have worse results with subq if I had to put a number on it. By worse results, I mean any combination of the following: lower serum T for a...

GLP-1 drugs can definitely reduce libido. This is a well known effect and it is dose-dependent, becoming apparent or worsening as dose increases. It does seem to relate to a global dampening of the reward system and desire/craving for all types of reward.

https://www.psytoolkit.org/experiment-library/ https://www.cognifit.com/ https://www.brainhq.com/ Yes, but you have to take all of it with a grain of salt. It's pretty obvious that taking these hormones can affect how you feel, sometimes very dramatically. 163 ng/dL

It's helpful, but it's still very possible to develop atherosclerosis at LDL levels that low and even lower. The book that Guided recommended, The Clot Thickens, presents many examples of this, as it unravels the cholesterol hypothesis of CVD and convincingly advances an alternative hypothesis...

It's funny how we tend to assume everything that goes wrong when we're on TRT is caused by our protocol. I did the same thing a few months ago when I was in the preliminary stage of coming down with covid and feeling awful.

Why did you stop using the estradiol valerate? Were there no subjective benefits associated with the higher E2? I think even if there weren't, you'd probably be safer from a health standpoint running your E2 between 30-50 than 10-20.

I almost said something in my previous post about Cortex normalizing ridiculous doses of prop. So I'll say it here: the doses of prop he suggests are insane. The deep troughs on prop let you "get away with" crazy high levels during the day, without the degree of side effects that would...

Varies widely, but I would say the possible ranges are something like this: Total T: 75 - 200 ng/dL Free T: 2 - 4 ng/dL E2: 10 - 25 pg/mL

I imagine there is some point where they stop replacing it but I haven't reached that point yet. Maybe two years from now when this third ring dies, they'll tell me I need to buy something new. Yes, topical testosterone drives E2 up, like most other forms of testosterone. Only oral...

Trying 3 mg daily. Yes, you run it with testosterone.

It depends how long ago you purchased it. Older batches contained real DHT, although only ~10% rather than the advertised 20%. Current batches contain testosterone, which will produce a significant amount of DHT after application. You may not be able to tell the difference if you are not an...

Injectable DHT is the new thing: 5AR Society

They replace the ring for free when the battery dies. I bought my original Gen 3 ring in 2021 and had it replaced twice now for free, once in 2023 and again just recently. Absolutely essential. I'm skeptical of scrotal cream for the purpose of counteracting high estrogen. Yes, you get...

I'll take you down the same path of exploration that I took. Beware, you may become either better informed or cleverly misinformed. I cannot vouch for the accuracy of this information as I have not had time to dig into all of the references. What is the contribution of serum DHT to AR...

There's some tension between a study like that, which shows some relationship between movement of serum DHT/ E2 and symptoms, and what we understand about the physiology of sex hormones in the CNS. In men, only testosterone crosses the BBB in any significant quantity, and at high physiologic...

Good. Now you'll want to keep things consistent and unchanged for long enough to learn something useful about the longer-term effects of this protocol. You answered your own question. Oura ring. I think that is more true for some side effects (hematocrit) than others (hair loss)...

I'm a glutton for punishment so I will be trying again with a lower dose. DHT enanthate first though.

If I understand correctly, the precursor hormones to testosterone that are produced in the testicles are not supposed to "leak out" under normal circumstances. They are instead consumed in the process of manufacturing testosterone. It is only with relatively massive doses of hCG that you can...

All I got out of hCG was a bunch of E2. The preg/prog/17-OHP and presumably allopregnanolone that I was expecting to rise all remained bottomed out. DHT/E2 ratio almost halved. ChatGPT led me to believe this low dose daily hCG was going to be an efficient way to raise most of the...

For better or worse, most people are able to adapt to the stimulating effects and sleep normally.

I haven't given up on it permanently, just for the next few weeks. Although, I should also receive some DHT enanthate this week, so I will probably be more tempted to try that before another hCG experiment.