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I just noticed your response in another thread which anticipates some objections: Retatrutide is going to improve your insulin sensitivity, increase your metabolic rate and help you burn fat whether you are experiencing significant appetite suppression or not. I would suggest not necessarily...

I haven't really heard of sub-replacement doses of thyroid doing much useful. What you're proposing will reduce TSH and your total and free t4, and will probably not significantly increase total or free t3 AUC. If you think being on the higher side of thyroid hormone is desirable (even high...

DHT / E2 ratio + enclomiphene ER antagonism is relevant for tendinopathy. You might experiment with removing enclomiphene and see if the tendons improve without the estrogen antagonism. Enclomiphene is also keeping your SHBG high, and yes, it is also the reason for the normal levels of LH /...

True. However, when you dig into mechanisms for higher testosterone to reduce reproductive success in an ancestral hunter-gatherer scenario, you realize that some are no longer relevant, while others are easily mitigated or monitored to avoid. You could even argue that higher levels would be...

Turn the A/C up to fix your injection pain. Who would have thought?

I would guess the alcohol isn't dry yet. Do you swab before or after drawing up the injection? I swab beforehand so that the alcohol will be dry by the time I inject.

Took 2.5 mg yesterday morning. Felt overstimulated in the first part of the day, mediocre in the afternoon, completely crashed in the evening. Didn't want to repeat that today. Going to shelve the idea for now.

"The golden mean, or golden middle way, is a philosophical concept, primarily associated with Aristotle's ethics, that emphasizes finding a virtuous middle ground between two extremes, one of excess and one of deficiency. It suggests that true virtue lies in moderation, avoiding both extremes in...

I ran some ChatGPT deep research on the behavioral effects of hCG-derived neurosteroids in men on TRT that you might find interesting. Behavioral Effects of hCG-Induced Neurosteroids in Men on TRT Context: In men undergoing testosterone replacement therapy (TRT), adjunctive human chorionic...

There is no longer any such thing as compounded hCG due to changing regulations. My impression is that most people these days are using Indian generic brands of hCG due to the drastically lower cost than pregnyl. The eutrig brand I'm using is a urine-derived hCG with a good reputation for potency.

I agree. If you are trying to minimize hematocrit increase with topical you'll want to apply only once daily in the morning. We see men applying in this manner reach > 1,000 ng/dL total T at the peak and yet still have detectable LH levels > 1 IU/L due to the overnight trough.

Treat sleep apnea, stop smoking if you do smoke, lose weight if you are overweight, improve insulin sensitivity if you are insulin resistant, increase cardio exercise. Your hormone levels are not high enough to produce excessive hematocrit in the absence of other contributing factors. I would...

I saw Bryan Johnson is taking 81 mg 3x weekly, which appears to be a compromise to gain some of the anti-cancer and CVD benefits without significantly increasing bleeding risk. I might do the same thing.

I'm going to try 2.5 mg orally again now that I'm old enough for it to make sense (almost 45). ChatGPT keeps telling me to try it for various reasons. Started today. I'll let you know how it turns out.