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  1. G

    Peptides for arthritis?

    I'm happy to hear you're making progress. I looked back through this thread and I didn't see whether you have tried BPC patches (not injections, not oral). I've tried a bunch of things for what I think is a combination of a sciatic nerve issue and a hip joint issue, and the patches seem to be...
  2. G

    Metformin Decreases Muscle Gain and Strength in Seniors

    1700mg per day is, to me, an insanely and unnecessarily high dose. Constant use would make it worse. I use 250mg of metformin (or berberine) prior to a high carb meal, and that is only once or twice per week. I also try to make sure I have some light activity after such a meal which further...
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    The Molecule Behind Energy, Recovery, and Aging (And How to Protect It)

    I've seen other Doctors (e.g. Elizabeth Yurth) make the case that the best way to raise NAD is to reduce the enzyme that breaks NAD down (which Apigenin does, among other things.) It doesn't look like they cover that here.
  4. G

    from needles to pills: the trt switch i didn’t expect to matter this much

    I'm well aware, however my approach to lack of authenticity, whether human or machine (which, sadly, is becoming more common in both cases) is to respond with authenticity, which will hopefully encourage authentic responses from someone and benefit other readers. I'm actually kind of glad the...
  5. G

    from needles to pills: the trt switch i didn’t expect to matter this much

    Nandrolone seems to help all around, however BPC and DMSO are my primary go-to's for joint pain, but I like having a small amount of N in the mix as well. As far as troches go, I always like to look for ways to improve and I seem to feel fractionally better when my T is at a trough, so perhaps...
  6. G

    from needles to pills: the trt switch i didn’t expect to matter this much

    I'm glad it's working for you, but there are some other important considerations that I think the wider population of people on or considering TRT would want to take into account. - Injections and creams have decades of crowdsourced knowledge about how to fine-tune them for an individual...
  7. G

    Oxandrolone - experience with dose and lab changes

    I've used Oxandrolone as an adjunct for a number of years and have a few observations. - If you're not already close to your genetic limits before starting, the benefits may not be distinguishable from what you would have gotten from simply continued consistent training, unless you are using...
  8. G

    The new science of alcohol

    While I would never suggest that someone start drinking and I've seen the damage that comes from people having a bad relationship with alcohol (or other addictions), the recent anti-alcohol push seems deceptive on several fronts. First, most of the articles say "as little as 1-2 drinks per day...
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    CJC-1295 vs Ipamorelin vs Tesamorelin vs hGH

    One of the best hernia Docs is apparently in Jacksonville FL. If you search on the Mercola.com site you should find an interview with him. Dr. Mercola had a hernia and that is who he used. Yours may be a different type but it sounds like it is worth watching. The main thing I remember is that...
  10. G

    Prostamax Bioregulator Peptide / Rejuvenate the Prostate

    Thanks for publicizing this. Have you found any reports of its effect on PSA or cancer-related impacts in general?
  11. G

    I can’t quite figure out how much to eat and of what

    That looks like a great starting plan to me and you can adjust based on how you feel. There's nothing wrong with a 9 or 10 day "week". That's how I used to train when I had the schedule flexibility. Some people do well on low carb and some don't. I find that I can get fairly lean on 100-300...
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    I can’t quite figure out how much to eat and of what

    Regarding calories, the whole point is to reduce overall calories while maintaining your metabolic rate, so the first question is whether your metabolic rate has already declined due to chronic calorie restriction or whether you are at a maintainable steady state. To be safe you could add 100...
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    I can’t quite figure out how much to eat and of what

    A few ideas. First, congratulations on the progress you've made so far! You're way ahead of many people. - For diet in general, I recommend people use the book Perfect Health Diet by Paul Jaminet as a home base, but it sounds like you are fairly close to what he recommends. - IME seed oils are...
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    The Coronary Calcium Paradox: When Higher Scores May Mean Safer Arteries

    The problem with this reasoning AFAIK is that calcified arteries are not good either since the artery is supposed to be flexible and calcification prevents much of the flexibility. What is supposed to happen to the soft plaque is that the body grows a new layer of endothelium over it and absorbs...
  15. G

    Frustrated with bloodwork. Daily injections, lowered dose, no AI.

    I have found the same thing. Hydration is critical to the point where I am drinking water it the waiting room for my blood draw. Be thankful you are optimized in what matters. Feeling great with high E2 is IMO better that feeling great with low E2, which is a problem for some of us. I wouldn't...
  16. G

    I just started Wegovy yesterday.. Nauseous already :)

    You make a good point here that I think deserves emphasis. The bulking and cutting rollercoaster that has become almost standard in the lifting world is the very opposite of consistency and I think leads to a lot of bad outcomes. In particular I notice a lot of people who over a period of a few...
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    Gene's Nitric Oxide Stack

    If your doctor won't provide one, many of have ordered from alldaychemist with good results. Also note that there are now Nitric Oxide lozenges available which have only been out in the last year or two.
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    A bit frustrated right now after my first appointment...

    I echo Nelson's comment. Hormone/health optimization is not about a few numbers on paper but about wholistic life approach. Defy are well-regarded specialists and have lots of option available as well as specialized expertise. Reading between the lines, it sounds like the doc you went to is...
  19. G

    Minimum testosterone to get a growth advantage

    - I am not sure of all of Primo's impacts, but it seems to me that oxandrolone is the lowest risk anabolic option for what you are after since lowering your T dose should lower your E2. -I was referring to GH secretagogues, not GH, although GH is fine to try to. IME it is lower risk than...
  20. G

    Minimum testosterone to get a growth advantage

    I agree with Nelson that oxandrolone and nandrolone (preferably NPP to start with, IMO) are better add-on options. Primo seems to blunt sex drive in some people, possibly due to its interference with E2 and IMO is overrated unless that doesn't happen for you. Oxandrolone at a low dose like 10-12...
  21. G

    Ancedotes of feeling better when taking time off injections.. Science behind this?

    Another avenue to explore is the degree to which Testosterone is a "signaling" molecule which trigger effects that last long after the actual T (and possibly metabolites like E) are out of the system. I don't know the biochem in detail, but we have had people here who for example were injecting...
  22. G

    Skipped 3 pins and felt great

    There are many points of view on this topic, but my two cents is to try going without pinning for as long as you can and then when symptoms reappear, inject a low-moderate dose and repeat the process. T is (among other things) a signaling molecule and some people may do better at much longer...
  23. G

    Tinnitus

    I find potassium supplementation to be step one for BP. Contrary to popular belief, low salt can also cause high BP in some people. Cold temperatures can also cause a seasonal rise. It seems like trying other meds like telmisartan or possibly an ACEi is worth a try since tinnitus can be...
  24. G

    Improved transurethral medication for ED.

    ok, thanks I'll check it out. Hopefully they have a telemedicine option since i don't have a regular doctor.
  25. G

    Is my ED physical, psychological or hormonal?

    A general comment; erection quality is always a combination of things across the spectrum you listed, as well as others such as pheromone-like signaling from your partner. My approach and recommendation is to always be looking to maximize all of them as best you can. It's way too complicated to...
  26. G

    Took 4 days off my EOD injections and feel great. Need advice

    As Funk implies, there are simply too many variables and too little understanding of them to know what will happen, especially at the individual level, without experimentation. We have had posters here who seemed to do with injections at fairly long intervals so you may be one of those people.
  27. G

    Tinnitus

    Do you have a home montitor and have you done multiple readings at a time to see the fluctuation? What have you tried to bring it down?
  28. G

    Switched from TRT to Enclomiphene...surprising results

    Early in my TRT journey I used to come off for 6-8 weeks per year, and 6 weeks was usually not enough to recover my pre-TRT levels, so waiting some more and upping your dose (if it does not produce negative symptoms) seems reasonable. Also consider what else might affect your levels such as...
  29. G

    Prescribed 200mg of Nandrolone

    If you were in a good place with the 60mg, I see no reason to change. Consider yourself lucky to be dialed in and don't change for the sake of change. You can use the higher script to build up a back-up supply. If you raise the Nandrolone dose, you might also be fine on a lower T dose if your E2...
  30. G

    Improved transurethral medication for ED.

    So what does that work out to for cost per use? I experimented with something similar from a different pharmacy just to have as fallback plan, but the price worked out to about $35 per use which is way more expensive than bimix per dose (which I don't use, but which would be the alternative for...

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