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You aren't going to lose weight and gain significant muscle at the same time, so let's assume you are prioritizing weight loss first. GLP-1, preferably retatrutide, done. Add keto / carnivore diet for extra credit and the ability to maintain the weight loss without a GLP-1 drug.

I concur with Phil on what you should do. You should drop your TRT dose back down, restart the hCG, and tune the dosage of both so that the sum total E2 produced does not require an AI to prevent side effects. This is going to give you a better quality of life, good sexual function, and...

I still think it is going benefit most people, and hope you won't be discouraged from your own experimentation. With my history of accutane and SSRI use, I am likely broken in some unique ways. And I will probably still try a lower dose again, when I return from vacation. Sleep has not been...

This experiment has not gone very well for me so far. I've been on hCG for over a month now, with some varying doses at first but settling at 150 iu daily, combined with 15 mg test cyp daily. I did feel some improved sensitivity in the beginning, which went away. I also noticed signs of life...

My labs while running ~19 mg test prop daily, MCT oil, shallow IM in ventroglutes: Peak (labs taken 5.5 - 6 hrs after injection) 49 ng/dL Free T 56 pg/mL E2 Total T: 1818 ng/dL Trough (next morning 8 am) 19 ng/dL Free T 22 pg/mL E2 Total T: 840 ng/dL Yes, you can do that. You just draw up...

Ironic that this sugar alcohol which health conscious people used to avoid the harms of sugar turned out to be much more harmful than sugar.

Look WIlly, this is my clinic, so you're going to take your supraphysiologic dose and like it! Now go out and enjoy life in your new suspiciously athletic body.

Agreed. Maybe some minor sarcasm here and there, nothing serious. Hats off to you sirs, for an entertaining discussion between gentlemen.

No, I'm caffeine-free. I would guess it was the amphetamine metabolites causing most of the noticeable effects, as I took one sublingual dose some months ago and didn't really feel anything noticeable at all.

Vince makes a good example patient. If lean and mean, low-aromatizing Vince rolls into your TRT clinic on his Harley, and you give him 50-75 mg a week, he's going to have single digit E2, hate his life, and hate you. Needless suffering indeed!

Everything else being equal, more frequent injections usually produces lower hematocrit levels than less frequent injections. With E2, you're probably going to see that go up, only because your trough level is now higher. Don't treat the E2 number though. If you don't have estrogenic sides...

If I may insert a thought here, I don't think starting everyone either higher (100-120+ mg) or lower (50-75 mg) makes sense. I think with some baseline testing and information gathering, you can predict with pretty good accuracy (not perfect accuracy, but reasonable accuracy) who is going to...

Yes, this was all very normal. E2 was probably on the high side because of the extra fat you hadn't lost yet. You seem to correctly understand that the cause of your symptoms was probably stress, and not testosterone deficiency. There are different schools of thought around TRT and...

Yes he has news. @Jerajera

What were your starting levels and symptoms that led you to a hormone optimization clinic? You haven't mentioned free T yet, and that needs to be talked about (your original baseline and what it is currently), as that is far more important than your total testosterone. It can be calculated from...

You're taking too much of everything. You don't need to be at 1376 ng/dL to get someone pregnant. I bet you could get the job done fertility-wise with a lower dose of enclomiphene like 6.25 mg, no hCG, no AI, and feel a hell of a lot better than you do now.

Yes, DHEA can absolutely contribute to elevated estrogens, not just E2, but E1 as well (estrone). Yes, it can and does often make people feel like crap. Experimenting with cutting it out is a great idea.

My vote would be 25 mg twice weekly.

Just the opposite - it is inexpensive and easy to get, as long as you are comfortable ordering from indian pharmacies. https://www.reliablerxpharmacy.com/catalogsearch/result/?q=hcg

Replying to one of your previous threads would provide context and hopefully a history of protocol changes and labwork. Without that it's difficult to advise. It's certainly possible. Can you be more specific about needle size, injection location, body fat percentage? How much fat can you pinch...

It seems like no lab work has been performed, which is a grave mistake. You'll need to do that before any further hormonal experiments. However, if clomid improved your libido, that's a strong signal that the low libido has a hypogonadal cause. So, you're going to be disappointed to learn that...

We can't see your SHBG from the previous level, which makes it impossible to determine if there was any difference in what matters (free testosterone and free E2). It is quite possible that your SHBG dropped from the previous lab which would cause a drop in total T and E2 without there...

As I said, the retatrutide is assisting your fat loss whether you are feeling the appetite suppression or not. That entirely depends on your source. I'll show you what's reasonable (prices are for a "kit" of 10 vials) - if you paid more, you overpaid.

I just noticed your response in another thread which anticipates some objections: Retatrutide is going to improve your insulin sensitivity, increase your metabolic rate and help you burn fat whether you are experiencing significant appetite suppression or not. I would suggest not necessarily...

I haven't really heard of sub-replacement doses of thyroid doing much useful. What you're proposing will reduce TSH and your total and free t4, and will probably not significantly increase total or free t3 AUC. If you think being on the higher side of thyroid hormone is desirable (even high...

DHT / E2 ratio + enclomiphene ER antagonism is relevant for tendinopathy. You might experiment with removing enclomiphene and see if the tendons improve without the estrogen antagonism. Enclomiphene is also keeping your SHBG high, and yes, it is also the reason for the normal levels of LH /...

True. However, when you dig into mechanisms for higher testosterone to reduce reproductive success in an ancestral hunter-gatherer scenario, you realize that some are no longer relevant, while others are easily mitigated or monitored to avoid. You could even argue that higher levels would be...

Turn the A/C up to fix your injection pain. Who would have thought?

I would guess the alcohol isn't dry yet. Do you swab before or after drawing up the injection? I swab beforehand so that the alcohol will be dry by the time I inject.

Took 2.5 mg yesterday morning. Felt overstimulated in the first part of the day, mediocre in the afternoon, completely crashed in the evening. Didn't want to repeat that today. Going to shelve the idea for now.