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that is a good point, hypothyroidism people can have same issue with Progesterone

that is so interesting, I just increased the dose since Thursday from 1mg to 1,5mg and switched to abdomen, and I feel crazy again, erections and wild sex thoughts, I would say overly exited and feeling wired, which is just the opposite of Progesterone. I just think I may not doing well...

@FunkOdyssey where did you inject your Pro, and for how long you did you try it? It is interesting comparing my response to yours, typically you would expect your response from Pro. Was your Pro suspended in sesame oil as well?

I have been reading for the past several months the work of Ray Peat. He studied Progesterone and Estrogen extensively since the 70"s I believe. He understood the importance of Progesterone, and figured out that the best route of administration is micronized Pro dissolved in Vitamin E...

Hi Vince, I have been using the injectable since November. I'm sure it is not placebo, the benefits and sides are noticeable and dose dependent

Progesterone scrotal

thanks. I started to think about this possibility when I was reading an article that compared SC vs Transdermal administration of DHEA, with SC increasing more estrogens. I'm going to try to change injection site and check levels again, see if I get a better response from it in an area with...

I haven't, thanks for suggesting this.

thanks for reading and replying. I can live with more body hair growth, but not feeling overly emotional. When I was on the scrotal cream, I didn't experience these side effects, and Pro level rose to top of the range, so probably discarding the sensitizing effect of Pro to estrogen receptor...

@Cataceous @Gman86 @JA Battle I would like to know your opinion on this I noticed that when I was on the 1,5mg or even worse at 2.5mg dose of Progesterone SC, I would experience some side effects such as being emotional, and way too much on the 2.5mg, and also more body hair growth, crazy...

my doc suggested to move the injection from night to am since I was having some sleep issues, I thought at the beginning it helped with that, but I'm actually don't think it was the issue. I want to try to move it at night again, since I find doing the injection at that time is more convenient...

1mg daily SC in the AM

@FunkOdyssey @Gman86 Have you guys seen a noticeable difference in labs going from Empower CYP to Hikma Enanthate?

I will probably take the test in a week or two, and then I will update you guys here.

Funny I was just looking into it last night, thanks for posting this. Ref range for adult males is ≤0.3 ng/m, I remember seen a study showing normal levels being <.9 ng, but wondering if the different assay leads to a different ref range.

@Vince do you think it is ok to reuse a bacteriostatic water btl even when the first time air was injected in the vial to draw the water out?

@Cataceous what would you estimate is the peak time and half life of a 2.5mg ( 0.05 ml ) Progesterone Injection suspended in oil injected SC, considering its IM peak time is "within 8 hrs" at 10mg ( .2ml )?

I thought I would use that spot because I already use the abdomen for daily HCG, but I always wondered if there is any difference in absorption between different SC spots for oily injectables. I'm no sure actually, my doc suggested to take it in the am since I was complaining of some sleep...

SubQ on the upper outer quadrant of my butt. I now take it every am, 1mg dose. I still have to look at where to get my LC/MS for Progesterone.

correct, I take a click of a Pregn cream once in a while but not all the time. I still want to try to include it on my protocol sometime in the future though.

I think this is really the most convenient place to buy insulin syringes, I can't find any better

keep us posted, I may actually take the LC/MS as well, I think there has been some inconsistency with my Progesterone testing since the beginning as well

anxiety and mood improved, some sort of fear of heights improved, I believe it improved my thyroid and adrenal function, better skin, erections sex drive and libido. I was hoping to see improvements in my sleep like other experienced in here, but I don't think I noticed anything in that regard

I’m currently use an injectable, which I find it works the best, more physiologic as it doesn’t make that first pass in the liver. I tried oral micronized IR and SR, cream or forearm and scrotum, I felt too moody with this and groggy at times, likely due to excess allopregnenolone. There is...

Interesting. I heard about the saturation for E2 and DHT with higher Test level before but never looked at the mechanism. The enzyme saturate, but doesn't "burn" as Mark Gordon mentions, perhaps in the brain it may be different. It is interesting to note also the saturation of the 5 ar start to...

I agree. In fact if injecting more Testosterone would "burn 5 alpha reductase" we would see a drop in DHT as well, but not quite I believe. On TRT, Progesterone needs to be monitored, and supplemented to raise levels. I don't know why this is not common practice for practitioners out there...

How is your Progesterone level?

I’m picking up my Test E from Hikma from CVS pharmacy here in LA. I will switch from TC empower in a couple of weeks when I finish the vial. Good talk in this thread @FunkOdyssey about the preservatives in T formulation, I will give an update once I’m starting the TE

since then, I changed my diet a little bit, . I started to eat more red meat and including beef liver weekly for copper, but I have never followed up with my copper level Serum copper it is not a good maker for copper status in the body. Testing Ceruloplasmin is a better way, perhaps along with...

@FunkOdyssey @Gman86 are you guys still using the Hikma Test E from Defy? I just checked their website and 5ml vial is $199? it seems way to much $ for 5ml test. Same brand can be found at CVS for $ 94 regular price, or $32 with Goodrx

I hear you. I ask Defy if any of the pharmacies can compound a Test in MCT oil but nothing, not sure why it is so hard to do.