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GLP-1 Therapy Clinical Guide Preventing Muscle Loss During Treatment & Weight Regain After Discontinuation Evidence-Based Strategies with Annotated References Executive Summary GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) have revolutionized obesity treatment, producing weight...

Kyzatrex: The Complete Guide to Oral Testosterone Replacement Therapy Curated By Nelson Vergel | ExcelMale.com | Updated January 2026 Introduction What if you could restore your testosterone levels to normal without injections, messy gels, or painful pellet insertions? For millions of men...

Naringin has emerging preclinical evidence for promoting hair regeneration, largely via Wnt/β‑catenin and antioxidant/anti‑inflammatory effects, but human data are very limited and it should still be considered experimental.sciencedirect+1 What the key studies show A recent animal study...

Understanding the Role of Neurosteroids, Upstream Hormones, and Practical Solutions Curated By Nelson Vergel | ExcelMale.com Introduction: The TRT Paradox One of the most frustrating experiences reported by men on testosterone replacement therapy (TRT) is the persistence of anxiety and brain...

DEEP DIVE: Strategies to Increase Allopregnanolone A Comprehensive Review for Mental Health Support 1. What is Allopregnanolone? Allopregnanolone (ALLO) is a neurosteroid synthesized from progesterone that acts as a potent positive allosteric modulator of GABA-A receptors. [1,2] Its potency at...

Palmitoylethanolamide (PEA) A Comprehensive Review of Mechanisms, Clinical Evidence, and Practical Applications January 2026 Abstract Palmitoylethanolamide (PEA) is an endogenous fatty acid amide belonging to the N-acylethanolamine family with extensively documented anti-inflammatory...

A Comprehensive Guide for Men Starting Testosterone Replacement Therapy Introduction: Finding the Right TRT Doctor Choosing the right TRT doctor is one of the most important decisions you will make on your hormone optimization journey. A knowledgeable TRT doctor can mean the difference between...

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Why Older Men May Need Less Testosterone: The Surprising Science of Metabolic Clearance 1. Introduction: The Hormonal Paradox In the world of hormone replacement therapy and longevity, the prevailing assumption is often that "more is better." If an aging man’s testosterone levels are naturally...

FDA Testosterone Regulation: The Complete Guide to Label Changes, Cardiovascular Safety, and the Future of TRT Access Curated By Nelson Vergel | ExcelMale.com | Updated January 2026 Is testosterone replacement therapy finally being recognized for what it is—a legitimate medical treatment rather...

Prepared: January 2026, Curated by Nelson Vergel Key Finding: Evolocumab induces significant coronary plaque regression and stabilization but does not differentially affect coronary calcium accumulation compared to statin monotherapy. However, PCSK9 inhibitors may slow the rate of CAC...

Diagnostic Assessment Strategy: Cardiovascular Risk & Systemic Health in Hypogonadal Patients 1. Strategic Framework for Cardiovascular Risk in the Hypogonadal Male In the contemporary clinical landscape, the management of the hypogonadal male demands a multi-modal assessment strategy that...

I am highlighting this opportunity to ask you to submit a public comment in support of TRT de-scheduling by 2/9/2026. Click here to add your comment: Federal Register :: Request Access Key Points to Include in Public Comments: When submitting comments, individuals should emphasize that...

Introduction: Why Exercise Matters More on TRT Are you getting the most out of your testosterone replacement therapy? For many men on TRT, the answer is no—and the missing link is often a properly designed exercise program. While testosterone therapy creates the optimal hormonal environment for...

Testosterone Therapy for Menopausal Symptoms Executive Summary This document synthesizes findings from a ten-year retrospective study on the use of subcutaneous testosterone pellet therapy for managing menopausal symptoms. The study, conducted at a single gynecologic practice, demonstrates...

What You Need to Know Scientists have discovered that the trillions of bacteria living in your gut don't just help you digest food—they also control how much testosterone your body has available to use. They're calling this system the "testobolome," similar to how gut bacteria also regulate...

L-Carnitine and CoQ10 for Male Fertility: The Complete Evidence-Based Guide to Improving Sperm Quality Curated By Nelson Vergel | ExcelMale.com | Updated January 2026 Introduction Could a simple combination of two naturally occurring compounds hold the key to improving male fertility? For the...

The psychedelic drug development landscape has reached an inflection point in early 2026, with Compass Pathways achieving the first positive Phase 3 psilocybin trial results in June 2025, while Lykos Therapeutics' MDMA rejection has reshaped industry expectations for regulatory rigor. Six...

A Comprehensive Guide to Current and Emerging ED Therapies for Men Curated By Nelson Vergel | ExcelMale.com | Updated January 2026 Introduction: Why ED Treatment Is Evolving Are you struggling with erectile dysfunction despite trying oral medications? You’re not alone. An estimated 322 million...

If you've spent any time on men's health forums, Facebook groups, or Reddit, you know the information surrounding HCG (Human Chorionic Gonadotropin) can be a dizzying mix of personal anecdotes, "bro science," and conflicting advice. It's a crucial component of many Testosterone Replacement...

COMPREHENSIVE ANALYSIS: Death with Dignity Legislation Progress Across All U.S. States (2025-2026) January 2026 EXECUTIVE SUMMARY As of January 2026, death with dignity (also called medical aid in dying or MAID) is experiencing significant momentum across the United States. Currently, 13...

Are your blood pressure medications affecting your erections? This is one of the most common questions men ask when prescribed antihypertensive therapy—and for good reason. Many men on testosterone replacement therapy (TRT) also require blood pressure management, creating potential concerns...

Here they are: "Why is 200 mg/wk the 'upper limit' for TRT?" - 219,000 views Why is 200 mg/wk the "upper limit" for TRT? - Excel Male Health Forum "Videos: Injecting testosterone and HCG" - 128,000 views Posted by Excel Male on Sep 30, 2013 - HCG plus TRT to Prevent / Reverse Testicular...

Could a single weekly injection deliver unprecedented weight loss while preserving muscle mass and improving cardiovascular health? For men on testosterone replacement therapy (TRT) struggling with stubborn body fat despite optimized hormone levels, this question has taken on profound...

If you've ever tried to figure out the right way to use protein for muscle growth, you've likely been buried under an avalanche of conflicting advice. From gym bro-science and supplement marketing to well-meaning but outdated tips, the noise can be deafening. The fitness industry is a...

Are you tired of painful intramuscular injections and wondering if there's a more comfortable way to administer your testosterone replacement therapy? For decades, intramuscular (IM) injections have been the standard method for testosterone delivery, requiring long needles, deeper tissue...

By Nelson Vergel | ExcelMale.com | Updated December 2025 Introduction Should you take an aromatase inhibitor with testosterone replacement therapy? This question has sparked considerable debate in men's health circles, with some clinics routinely prescribing anastrozole alongside TRT while...

By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a single number that tells only part of the story. What many don't realize is that a protein called sex hormone binding globulin (SHBG) determines how...

The Libido Misconception For most men, a lagging sex drive triggers an immediate, single-minded thought: "It must be my testosterone." While T is a key player in male vitality, this assumption often misses the mark entirely. Libido is far more than a single hormone; it's a sensitive indicator...

Many men begin testosterone replacement therapy expecting their sexual function to improve across the board—better libido, stronger erections, enhanced satisfaction. And while TRT often delivers significant benefits for desire and overall sexual activity, the evidence tells a more nuanced story...

Summary: The TRAVERSE trial, a landmark FDA-mandated study involving over 5,200 men, has definitively concluded that testosterone replacement therapy (TRT) does not increase the risk of major cardiovascular events like heart attacks, strokes, or cardiovascular death when administered at...