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I do take it orally, on waking with an empty stomach.

Yes, I've been taking 2.5 mg/day consistently.

I've taken the first one, which is to investigate where the missing testosterone went. It appears likely that the filtering action of a small needle is part of the problem, along with wastage via particle deposition on the vials. The empty vial that had contained 1 mL of the TS and 1 mL of...

If you're including testosterone suspension in this then yes, I am using it as a form of TRT. As documented here, I recently tried measuring the response over time. My protocol has involved injecting a nominal 1.5 mg three times a day. But based on lab work I'm beginning to suspect the actual...

This is very much in line with my thinking, particularly the part about a longer HTPA shutdown being more problematic. In my case the addition of hCG was an improvement, but it never led to consistent libido and/or sexual function, and things still went downhill over the years. Dropping the hCG...

Lately I’ve been insinuating that some testosterone suspension products may qualify as fast-acting, and therefore be in the same league as testosterone nasal gels and buccal troches. The “fast-acting” quality is important if the goal is to retain HPTA function in the presence of exogenous...

I do believe that TRT in just about any form is preferable to hypogonadism. However, now that we have an increasing number of choices that are less disruptive of the overall hormonal milieu I would hope these eventually become the new standard of care.

These are all relatively short and with small N, as they acknowledge: "A large number of clinical trials with relatively small numbers of participants, have been conducted to investigate the effects of testosterone, for generally limited durations of intervention, on various cognitive function...

As noted, GnRH may play a role in adult neurogenesis. Also in the post I linked to: ”[1] Furthermore: “Multiple lines of evidence indicate that the expression of extrapituitary GnRH receptor is not limited to reproductive tissues. For instance, it has been demonstrated by RT-PCR and Southern...

Which studies evaluated the rates of dementia? Healthy controls or just untreated hypogonadal subjects? What's needed to answer this question more definitively is a study with large N that has matched eugonadal men as controls. The study needs to last long enough and/or have old enough subjects...

Regardless of whether the testosterone is endogenous or exogenous, the fraction that is aromatized is trivial, and you'd be unable to detect such an increase, subjectively, or even with current lab tests. On the other hand, knocking down a big fraction of estradiol is what can cause significant...

That's good to know and nice work by Maximus. It sounds like I may be able to add it to the list of short-acting testosterone treatments. I still don't like the use of the term "bioidentical" to differentiate it from products that in the end also yield bioidentical testosterone. "Non-esterified"...

DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop. I should add that I'm ignoring the tiny amount of...

In this situation an aromatase inhibitor should not affect your free testosterone. It could indirectly affect total testosterone by reducing estradiol. Lower estradiol can lead to lower SHBG and therefore lower total testosterone as well. Your dose of testosterone has likely suppressed LH and...