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By the way, was just popping through studies again and found this one from '84: https://pubmed.ncbi.nlm.nih.gov/6693540/ If I am reading it correctly, basically, the leydig cell desensitization is related to an increase in 17-hydroxyprogesterone - I believe 17-OHP is largely produced in the...

I have heard about it, though I have not seen any studies about it nor have I really noticed anything that makes me think it's happening to me, with the exception of having to slightly increase my dose from ~2000iu/wk to ~2275iu/wk after three years, but that could be due to any number of...

Huh, I'd never put this together. I've been on HCG Monotherapy for many, many years now and I do randomly get very congested some mornings. I'll pay closer attention and see if I notice a connection with my dosing protocol.

re the above, I may switch to slightly higher dosing EOD due to the "feeling like a pincushion" thing. I'm just getting tired of poking myself with a needle every single day and there are only so many spots where I have enough subcutaneous fat to do it. Maybe go up from ~350iu/day to ~700iu EOD...

Bloodwork from last month: Total T: 644ng/dL, once again at 11am after a night of restless sleep (my sleep has been very hit or miss over the last few months due to stress). Estradiol: 21pg/mL SHBG, LH, FSH not tested due to HCG interfering with reliability of results Hematocrit: 47.4% I feel a...

Howdy, 1. It is possible that these are interfering with my sleep, but short of getting a sleep study done I don't have a way to verify that. I generally feel alright when I wake up, but the side effects of me not taking these medications are worse than "fatigue" so I intend to stay on them...

Hi folks, I've skimmed the above but I would just like to say that I already eat a pretty good quantity of non-starchy fruits and vegetables. I am fortunate enough to live a block from a weekly farmers market and as a result I get 4-5 servings a day (not perfect but better than most) of...

E2 will be part of the upcoming hormone panel. I have not done regular testosterone as I have generally had good success with HCG mono, though I am aware that eventually I will likely have to make the switch. Good point on the long-term meds issue, though as I need to take these medications I...

Thanks, I should have mentioned the following details - 1. I've been on the same dose of all meds other than the GLPs for at least five years now, so I don't think it's those. 2. I took a month off the GLPs and ate at maintenance during that time to rule out both "GLP Side Effects" and "Fatigue...

Bumping again. I've asked my urologist to order the above, but just for a laugh yesterday I took an iron supplement (25mg of chelated iron with breakfast). I had horrible gas pains about six hours later and don't think I've ever farted that much in my life, but felt significantly less run down...

Well, looks like my urologist's office forgot to order the lab work for my hormones today (which is fine, this was like fifteen minutes out of my day) so I'm going to call them on Monday and ask them if they're willing to order a full thyroid panel and an iron/ferritin screen. Anyone else have...

I never updated this, sorry. Blood work and genetic testing with the holistic doc showed pronounced dysfunction in the expressions of leptin, ghrelin, adiponectin, melanocytes, PPARG and PPARGC1A, Vitamin D receptors, estrogen receptors, and insulin receptors, as well as, oddly, genetic markers...

I mercifully have not had that issue. As I may have mentioned in other places, I kept 100lbs off for many years and then just got stuck. I tried absolutely everything, every possible diet, exercise routine, you name it, for years, and nothing worked. I was absolutely miserable. I finally got...

for whatever reason, the consensus - which I happen to agree with from personal experience - seems to be that Pregnyl is just better than any other HCG. Other than that it's kind of a wash, I've used ZyHCG, Sifasi-HP, and I think Corion and they were all "fine."

Boy, I could not have seen this thread at a better time. Lots of low iron symptoms over the past few months (I am on HCG rather than TRT) and blood work showing high hematocrit and low MCHC. I'd been suspecting ferritin.

Hi Folks, For the past two months or so I have been suffering from a number of odd symptoms, including extreme fatigue, brain fog, lack of motivation, shortness of breath, difficulty regulating my body temperature (sometimes very hot when cooking in an air-conditioned kitchen, or very cold...

Just as a sidebar, I had a check-up with my primary care doc yesterday for unrelated reasons - his thinking in looking at all of my labs, charts, etc from the past decade or so is that a GLP-1 is probably the move, especially given the fact that I haven't regained any weight from the last time I...

Thanks for the insights, y'all. I have taken @Guided_by_Voices' suggestion and booked an appointment with a well-regarded and highly-recommended holistic/functional medicine doctor in town who specializes in weight loss and hormone issues. I'd just like to make sure there isn't an underlying...

Hi y'all, for a bit more of my background (optional) I have a thread here about being on HCG Monotherapy for many, many years: Long-Term HCG Monotherapy Results and that'll go into some specific blood work. But here's the situation. I have kept 100lbs off for over a decade and cannot get the...

Howdy! Most recent bloods showed my Total T at 589ng/dL, which is a little bit low but it was at 11am and I did not sleep well at all the night before. E2 has also increased to 45pg/mL, which is higher than we'd like. We've put me back on a half mg of anastrozle per week and are going to...

Cheers, thanks! I've got blood work coming up in the next week or so and I'll try to remember to post my results. Anecdotally I still feel completely fine - I can still perform in the bedroom and I'm gaining muscle in the gym, no real issues there. One weird issue is my body fat distribution...

Huh, I am completely unfamiliar with this. Down the rabbit hole I go, I guess?

oh yeah, I factored a month of shipping time into my decision, but it's now been six weeks and they're still in Germany. Completely unjustifiable system we have here. Why did the new cheap generic increase in price 1000% overnight? Because fuck you, that's why!

Yes, secondary, thanks. And yeah, the only two things I can find about doing this are one guy who switched his HCG out for Kiss10 while already on test, but he posted on Reddit and hasn't responded to my threads or DMs, and one guy on T-Nation in 2022 who was taking 100mcg an hour and at that...

Yeah, I've got six vials coming, just didn't think German customs would hold on to 'em for 3 weeks on their way to the States.

Howdy y'all, As I've posted about in the past, I've been taking HCG Monotherapy for low T for about seven years now with good results - my last bloodwork had my total T at 707ng/dL with no change to my total weekly dosage since I started in 2017 (just tweaks to my dosing protocol)...

Bumping this out of frustration. The Fresenius Kabi generic has bumped up to $475 for a single 10mL vial, so I'm back to ReliableRX just because I can't afford that right now and I've found UGL HCG to be wildly unreliable in quality and potency. Is Reliable still the move? My order just finally...

Improving, but there’s a lot of other stuff going on there - as a formerly obese person my metabolism is quite slow, up until recently I worked a very sedentary job, and I take other medications that can impact body composition. I’ve actually got better insurance now and have already booked...

True! I meant it is higher than it historically has been for me and outside of the “normal” reference ranges for this lab, but you’re right, that context is important.

Six month update. I made no changes to my protocol other than dosing 300iu daily as described above for the reasons outlined in the studies above. I mentioned I felt great and the numbers bear that out: Total T 707 e2 39 (a little high but proportionately fine and I’m having no side effects...

Pregnyl has been out of stock/backordered at all of my local pharmacies for the last few months. I posted about this yesterday, but Rite Aid finally got me a generic HCG made by Fresenius Kabi, $199 for two 10mL vials, and my body seems to respond to it as well as as I've responded to Pregnyl...