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High prolactin can cause your symptoms! Your testosterone is not borderline. Do you take any medications?

Most interesting starting around 19 min Starting dose depends on baseline T level, age, health, shbg. Just another voice. Hope that distracts you both from your neverending debate ;) @Phil Goodman @Cataceous

IIRC oral converts through digestive pathway (much more) to preg sulfate which transports preg to the brain and servers as storage molecule. The dose matters, too much oral preg makes me tired. Which aspects of your life are improved by topical pregnenolone? What doses did you try (oral...

I use TU once per week. I suggest you first try once per week TC to achieve a more stable T level.

Thank you for sharing your experience. Seems like you got all the possible side effects of (super physiological testosterone) TRT.

DeepSeek voodoo **Important Nuances:** * **Lower Brain Concentration than Testosterone:** Despite crossing the BBB, DHT generally achieves lower concentrations in the brain *from the bloodstream* compared to testosterone. This is partly because: * **High Plasma Protein Binding:**...

How do we know that (for sure)? It will do something. Fingers crossed

Have to add that I'm skeptical about the prediction graphs. It looked appealing to me because of my recent speculation about E2 clearance and the role of it in the regulation of LH peaks. E2 regulated to be in physiological range and T being secondary. E2 'control' and/or addition of DHT is...

Estradiol non-linearity DHT up and E2 down seems a direction to explore. What you pointed out, your DHT to E2 ratio. No new information to you however nice plots https://pmc.ncbi.nlm.nih.gov/articles/PMC9016457/

Great experiment. Thank you for sharing!

ChatGPT imitates MDs With deepseek deep thinking activated I can follow the internal reasoning and ask critical follow-up questions. After few follow-up questions the output seems reasonable to me whether it's then accurate and unbiased is another problem.

I remember this. Sparse data above 800. After what time? Thanks for also posting the scatterplot. The origin is not zero, could draw the blue line closer to the red. However it nicely visualizes what is meant by saturation in this context. I measured after about 10 months. I'm the blue . Maybe...

I thought you wanted to try the HCG-base protocol You are right, 500-1000IU per week seems standard on top of TRT I understand.

Your protocol had no chance of success. Two options? Option 1) Carefully sprinkle T on top of hcg. Option 2) Carefully sprinkle hcg on top of T. Add: Considering the impact of E2 on your libido and the significant physique benefits you experienced on TRT.... ,ust a peer-reviewer thought: how...

I just found it interesting and wanted to share it, and luckily you guys can think for yourself. Thank you for the peer review. Appreciated!

While writing the first post I recalled your story of im vs sq. Maybe it's less the aromatization in your fat tissue and more the higher variation of your T level that balance T influx vs W2 clearance. And yes, thanks for clarifying my super brief speculation. TRT without hcg i.e. no...

I think this aromatase saturation happens far outside the physiological range. For me on TU, double dosis resulted in double max reference range levels of fT and fE2 (250mg vs 125mg). We humans trying to make sense of biological systems. Many traps because they are not by design...

Deep seek: Even when hCG is used to achieve *physiological* testosterone levels, there is **still a significant risk of excessive estrogen (estradiol) conversion** in men. Here’s why and how it happens: --- ### **The Science: Why Estrogen Rises with hCG** 1. **Aromatization Overdrive**: -...

DeepSeek * **United States:** Estimates suggest **4-5 million men** are prescribed testosterone therapy in the US. Usage has increased significantly over the last decade. * **Worldwide:** Global figures are harder to pin down precisely due to varying regulations and...

I laid out the ground work and was waiting for such comments.

Oh, nothing personal! Was wondering, if all men on trt would take hcg, how many pregnant women would we need to harvest for hcg per year. The whole pee aspect makes me feel uncomfortable. Luckily we have India I'm hoping for an esterified version of lh

Happy hunting my friend

According to DeepSeek you need about one pregnant woman per year to harvest your hcg. 80L of trimester urine for 52k IU ### The Standard Yield - **1 liter (L) of first-trimester pregnant urine** → Yields **≈1 mg of purified hCG** after industrial processing. - Since **1 mg hCG ≈ 650 IU**, this...

If I knew what my normal healthy level was before it crushed to about 150, that would be the reference value of my natural physiological T level. Unfortunately most of us do not have this datum. What can we do? We use the population normal distribution as reference. I would use the population...

Yes, it works for you. Perfect. I'm not judging, how could I based on the scarce scientific data. Table 2 baseline T levels: mean +- SE. There is variation between individual baseline levels. There is no need trying to justify your dose. At least not from my perspective. It's not about the...

My comment was about the (mis)interpretation of the study. Sticking to science and not making up things and jumping to conclusions that are not supported by the data. Everyone is obviously allowed to share his opinion and encouraged to share his experience. Everyone is free to experiment and...

Exactly that. If anyone cares, look at the baseline peak levels. Table 2 and table 7 for hemoglobin and hdl. This work did not aim to find the TRT dose for the study population. Read the discussion, limitations etc.

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16612 Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are promising...

I give up! AI succeeded humans in reasoning... I apologize for being rude. It's just so frustrating.

"My priorities are I want to keep the ability to perform in the bedroom, at the gym and not go through life having zero energy, brain fog, 2nd guessing and able to make a decision on anything." = TRT But that's not what you want: "Compared to where I was. 500ng/dl is amazing. But I don’t have...

Especially if one aims to prioritizes brain/mental health.